Re: Re: study encourages earlier vaccination

[Guest guest]

If I'm not mistaken they found in britain that putting off vaccines 2 months on the DPT a child had a better chance missing asthma. The vaccine program is not broken, it's in shambles.

I maybe wrong which vaccine though they all seem to be very dangerous as they are

Subject: Re: study encourages earlier vaccinationTo: EOHarm Date: Wednesday, November 5, 2008, 10:30 PM

This is one of the shots my son got right before his head swelled.CGF> > and may be an especially useful approach during outbreaks> > of pertussis," s said...

[Guest guest]

That was in Canada, I believe. A researcher in Winnipeg, Manitoba looked at the vaccine records of over 10, 000 students and found out this out, apparently. I was amazed by the fact that she was given access to so many vaccine records, when most epidemiological or even so-called "ecological" studies don't even look at anyone's actual vaccine records. I was even more amazed, actually dismayed, when this researcher did not call for a delay of these vaccines, based on the results of her own study. That was mighty perplexing! Anyway, here's the link to more info on the study:http://www.medscape.com/viewarticle/572891Aasa--- Subject: Re: Re: study encourages earlier vaccinationTo: EOHarm Received: Thursday, November 6, 2008, 4:49 AM

If I'm not mistaken they found in britain that putting off vaccines 2 months on the DPT a child had a better chance missing asthma. The vaccine program is not broken, it's in shambles.

I maybe wrong which vaccine though they all seem to be very dangerous as they are

From: thefitzenreiterfami ly <thefitzenreiterfami lyyahoo (DOT) com>Subject: Re: study encourages earlier vaccinationTo: EOHarmyahoogroups (DOT) comDate: Wednesday, November 5, 2008, 10:30 PM

This is one of the shots my son got right before his head swelled.CGF> > and may be an especially useful approach during outbreaks> > of pertussis," s said...

[Guest guest]

Here's part of the article:Delaying DPT Vaccination May Reduce Incidence of Childhood Asthma

CME

News Author: Laurie Barclay, MD

CME Author: Laurie Barclay, MD Disclosures

Release Date: April 14, 2008; Valid for credit through April 14, 2009

Credits Available

Physicians - maximum of 0.25 AMA PRA Category 1 Credit(s)™ for physicians;Family Physicians - up to 0.25 AAFP Prescribed credit(s) for physicians

To

participate in this internet activity: (1) review the target audience,

learning objectives, and author disclosures; (2) study the education

content; (3) take the post-test and/or complete the evaluation; (4)

view/print certificate View details.Learning ObjectivesUpon completion of this activity, participants will be able to:Describe

the relation between risk for asthma and delay in the administration of

the first dose of diphtheria, pertussis, and tetanus vaccine by more

than 2 months.Describe the relation between risk for asthma and delays in administration of all 3 doses.Authors and DisclosuresLaurie Barclay, MDDisclosure: Laurie Barclay, MD, has disclosed no relevant financial relationships.Brande Disclosure: Brande has disclosed no relevant financial information.April

14, 2008 — Childhood asthma is reduced by half when the first dose of

diphtheria, pertussis, and tetanus (DPT) is delayed by more than 2

months vs given during the recommended period, according to the results

of a retrospective longitudinal study reported in the March issue of

the Journal of Allergy & Clinical Immunology."Early childhood immunizations have been viewed as promoters of asthma development by stimulating a TH2-type immune response or decreasing microbial pressure, which shifts the balance between TH1 and TH2

immunity," write Kara L. Mc, MSc, from the University of Manitoba

in Winnipeg, Manitoba, Canada, and colleagues. "Differing time

schedules for childhood immunizations may explain the discrepant

findings of an association with asthma reported in observational

studies. This research was undertaken to determine whether timing of

diphtheria, pertussis, tetanus (DPT) immunization has an effect on the

development of childhood asthma by age 7 years."The

investigators analyzed data from the complete immunization and

healthcare records of a cohort of children born in Manitoba in 1995,

from birth until age 7 years. Using multivariable logistic regression,

they computed the adjusted odds ratio for asthma at age 7 years

according to the timing of DPT immunization.Among 11,531

children who received at least 4 doses of DPT, the risk for asthma was

halved in children in whom administration of the first dose of DPT was

delayed by more than 2 months. For children with delays in

administration of all 3 doses, the likelihood of asthma was 0.39 (95%

confidence interval [CI], 0.18 - 0.86)."We found a negative

association between delay in administration of the first dose of

whole-cell DPT immunization in childhood and the development of asthma;

the association was greater with delays in all of the first 3 doses,"

the study authors write. "The mechanism for this phenomenon requires

further research."Limitations of this study include possible

ascertainment bias; findings not yet confirmed with the diphtheria,

acellular pertussis, tetanus (DaPT) vaccine; and inability to refute

the issue of early-life infections as an explanation for the

association between delayed immunization and protection against the

development of asthma."Further study is vital to gain a detailed

understanding of the relationship between vaccination and allergic

disease, because a perception that vaccination is harmful may have an

adverse effect on the effectiveness of immunization programs," the

study authors conclude.The Canadian Institutes of Health

Research supported this study. Some of the authors have disclosed

various financial relationships with the Western Regional Training

Center for Health Services Research, the National Training Program in

Allergy and Asthma, the Canadian Institutes of Health Research,

Allergen, and/or Novartis. J Allergy Clin Immunol. 2008;121:626-631. Clinical ContextEarly childhood vaccinations may promote development of asthma, directly by stimulating a TH2-type

immune response or indirectly by decreasing microbial pressure. In

support of this hypothesis, an IgE response to vaccine antigens often

occurs in children vaccinated with diphtheria/tetanus, and this

response is more pronounced among individuals with atopy.

Epidemiologic evidence linking DPT immunizations to childhood asthma

is inconsistent. Some studies show an increased or decreased risk of

developing asthma, whereas others show no association. This study

assessed whether timing of DPT vaccination affects the risk of

developing childhood asthma by age 7 years.

Study HighlightsOf children born in Manitoba

in 1995, 11,531 children (82.6%) had received at least 4 doses of DPT

and were included in this study.These children were

primarily immunized with whole-cell pertussis DPT, because the DaPT

vaccine was phased in throughout Manitoba beginning in November 1997.The

investigators analyzed data from the complete immunization and

healthcare records of these children from birth until age 7 years.The

investigators used multivariable logistic regression to compute the

adjusted odds ratio (OR) for asthma at age 7 years, based on the timing

of whole-cell DPT immunization.Prevalence of asthma was 11.7%.Children

with asthma were predominantly boys (3:2) and lived in urban areas

(70.3%); 25% were from low-income homes; and 10.1% had mothers with a

history of asthma.The risk for asthma was decreased by

50% in children in whom administration of the first dose of DPT was

delayed by more than 2 months (OR, 0.50; 95% CI, 0.25 - 0.97).Sensitivity analyses that varied the interval for DPT immunization showed that these findings were robust.Asthma prevalence rates decreased successively from 13.8% to 5.9% with each month delay in DPT administration.Likelihood

of childhood asthma was also decreased after delays in the

administration of the second and third doses of DPT. Most of these

delays were in children with delays in their first dose.The

reduction in asthma risk for the second and third doses mainly resulted

from the delay in the first dose because there were no statistically

significant differences in asthma risk with delays in the second and

third doses in the absence of delays in the first dose.However,

for children with delays in administration of all 3 doses, the

likelihood of asthma was further reduced by 60% (likelihood ratio,

0.39; 95% CI, 0.18 - 0.86).Based on these findings,

the investigators conclude that there was a negative association

between delay in administration of the first dose of DPT immunization

in childhood and the development of asthma; that the association was

greater with delays in all of the first 3 doses; and that the

underlying mechanism requires further research.Limitations

of this study include possible ascertainment bias; findings not yet

confirmed with the DaPT vaccine; and inability to refute the issue of

early-life infections as an explanation for the association between

delayed immunization and protection against the development of asthma.

From: thefitzenreiterfami ly <thefitzenreiterfami lyyahoo (DOT) com>Subject: Re: study encourages earlier vaccinationTo: EOHarmyahoogroups (DOT) comDate: Wednesday, November 5, 2008, 10:30 PM

This is one of the shots my son got right before his head swelled.CGF> > and may be an especially useful approach during outbreaks> > of pertussis," s said...