CMT 1A and Neurofibromatosis type 1

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J Dermatol. 2009 May;36(5):306-11.

Neurofibromatosis type 1 associated with Charcot-Marie-Tooth type 1A.

Koc F, Guzel AI.

Department of Neurology, Cukurova University School of Medicine, Mithat Ozsan

Street, Adana 01330, Turkey.

Neurofibromatosis and Charcot-Marie-Tooth are genetic disorders of the nervous

system affecting the development and growth of nerve cells and demyelination of

peripheral neurons, respectively. We report a 22-year-old man who presented

clinical manifestations of both neurofibromatosis type 1 (NF1) and

Charcot-Marie-Tooth type 1A.

The simultaneous occurrence of neurofibromatosis and Charcot-Marie-Tooth disease

has rarely been reported. More extensive reports and further investigations of

this combination will certainly provide a better understanding of this linkage

in the near future.