Nature: A triple-antigen Helicobacter pylori vaccine is safe and immunogenic

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Nature Clinical Practice Gastroenterology & Hepatology (2008) 5, 656

doi:10.1038/ncpgasthep1287

A triple-antigen Helicobacter pylori vaccine is safe and immunogenic

[first paragraph[

Studies in animal models have shown that vaccination with recombinant

Helicobacter pylori vacuolating cytotoxin A (VacA), cytotoxin-

associated antigen, and neutrophil-activating protein (NAP) confers

protection against H. pylori infection. Malfertheiner et al. have now

shown that a prophylactic vaccine comprising these three conserved

antigens plus an aluminum hydroxide adjuvant is safe and exhibits

strong immunogenicity in H. pylori-negative individuals.