Muscle overwork leads to weakness - NO says Van Pomeren

September 23, 2009

All,

I have often heard Paolo Vinci cited on and in particular his work on

muscle overload leading to weakness.

As mentioned, I am a patient with the National Hospital for Neurology in the UK

and a participant in the CMT exercise physiology research studies ongoing. I

have a confirmed diagnosis of CMT1A - and am a very active individual constantly

seeking to redefine and understand my personal limits. Therefore, Vinci's

hypothesis fascinated me. I discussed it with the research team, and was

pointed to the following study by van Pomeren (et al) which I attached in the

folder " Exercise and CMT "

no overwork weakness_pomeren2007.pdf

Muscle Overwork Weakness in CMT patients - van Pomeren et al (2009)

The researchers disproved Vinci's study. This is good news for people like me,

who are concerned and interested in making sure that high activities levels do

not put them at risk of deterioration.

I also asked the research team if there was any link at all between the muscle

strengthening process - which stresses muscle cells to rebuild them stronger -

and the idea that nerves can be damaged in this process. They indicated to me

there was no physiological link between muscle strengthening and any nerve cell

damage.

I found both of these points to be music to my ears and wanted to share with you

all.

I will continue to post any updates to my questions that I think may be of

interest to the wider group.

Best wishes from London,

Donna

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