Vit.c Contraindications, Carcinogenicity & Mutagenicity

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Vit.c Contraindications, Carcinogenicity & Mutagenicity

Vit.c Contraindications, Carcinogenicity & Mutagenicity4.3 ContraindicationsAscorbic acid is contraindicated in patients with hyperoxaluria (Dollery, 1991) and G-6-PD deficiencyDoes anyone know what G-6-PD deficiency is? Is it a liver enzyme?

Does it have anything to do with not tolerating Sulfa drugs and/or Vit.C? 7.3 CarcinogenicityIt has been reported that there is no evidence of carcinogenicity (Dollery, 1991). However, some studies suggest that vitamin C may amplify the carcinogenic effect of other agents. Scwartz et al. (1993) report that L-ascorbic acid increases the oral carcinoma size induced by dimethylbenz(a)anthracene. Also, butylated hydroxyanisole induced forestomach carcinogenesis in rats (Shibata et al., 1993) and the K2CO3 induced promotion of bladder carcinogenesis in rats (Fukushima et al., 1991) were both amplified by the administration of ascorbic acid.Vit. C may amplify carcinogenesis..5 MutagenicityAscorbic acid is reported to increase the rate of mutagenesis in cultured cells but this only occurs in cultures with elevated levels of Cu2+ or Fe2+ . This effect may be due to the ascorbate induced generation of oxygen-derived free radicals. However, there is no evidence of ascorbate induced mutagenesis in vivo (Diplock, 1995).Here it says that Vit. C can increase mutagenesis in those with elevated levels of copper or iron. Don't most autistics have copper overload? http://www.inchem.org/documents/pims/pharm/ascorbic.htm