Rett syndrome vaccine induced?

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from 2002

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_ui

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J Child Neurol 2002 Sep;17(9):700-2

Fiumara A, Polizzi A, Mazzei R, Conforti L, Magariello A, Sorge G, Pavone L.

Department of Pediatrics, University of Catania, Italy.

Rett syndrome is a progressive neurodevelopmental disorder with a

well-defined clinical spectrum and course. Recently, mutations in the gene

encoding X-linked methyl-CpG binding protein 2 MECP2) have been identified as

the cause of Rett syndrome. Along with the classic form, variant forms of

Rett syndrome and Rett syndrome phenotypes are also recognized. We report on

a girl who, at age 2 months, developed an acute encephalopathy with

destructive brain damage 12 hours after acellular pertussis vaccination.

Peripheral lymphocyte subset analysis revealed the existence of T lymphocytes

double positive for CD4 and CD8 markers. This pattern normalized over the

following 3 months. Months later, the girl manifested a Rett syndrome

phenotype. DNA screening of the MECP2 gene was unrevealing in the child and

her parents. This previously unreported association emphasizes the notion

that Rett syndrome phenotypes can result from different (either genetic or

environmental) causes.