Re: Depakote in pregnancy increases risk of autism-- article Aasa

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From the " Chemo Brain " file on this list:

From what I understand of the article, Depakote induces:

programmed cell death (apoptosis) in a similar way to chemotherapy

chemicals; causes leukoencephalopathy (changes to deep white matter

of the brain), demyelinization (in two separate ways); destruction of

tubulin cells in the brain; HDAC inhibition (inhibits the

deacetylization of histone proteins in healthy cell nuclei); causes

Alzheimer's TypeII astrocytosis (because raised serum ammonia from

Depakote causes decreased glial uptake of glutamate, increased

glutamine); reduces synthesis of B6/folate; causes excessive levels

of homocysteine (as seen in Alzheimers and autism- i.e., disrupts

methylation).

The study is of a boy who regressed into " autistic-like behaviors "

after age 7 from Depakote (valproic acid or VPA).

Most or all of the above can be found in association with autism

and/or mercury/thimerosal in many studies. I suspect that somewhere

in the overlap is a key to proving mercury's potential role in the

epidemic.

> >

> > What about all those of who never took Depakote in pregnancy, or

at

> any other time? I would bet that there are way many more of who

never

> took Depakote, than the few who did.

> >

>