(CMT 2A): Mitofusin 2 Builds a Bridge between ER and Mitochondria

[Guest guest]

Cell. 2008 Dec 26;135(7):1165-1167.

Mitofusin 2 Builds a Bridge between ER and Mitochondria.

Merkwirth C, Langer T.

Institute for Genetics, Centre for Molecular Medicine (CMMC), and

Cologne Excellence Cluster on Cellular Stress Responses in Aging-

associated Diseases (CECAD), University of Cologne, 50674 Cologne,

Germany.

Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for

mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-

Tooth type 2A. In a recent report in Nature, de Brito and Scorrano

(2008) demonstrate a new function of MFN2-tethering the endoplasmic

reticulum and mitochondria to control the efficiency of mitochondrial

uptake of Ca(2+) ions.

[Guest guest]

Great. I have 2A and I am happy about the research, but I have no idea

what this means? (: