Do high-fat diets make us stupid and lazy?

August 12, 2009

New research in the FASEB Journal shows that high-fat diets are just as

unhealthful in the short term as they are in the long term

Short-term memory getting worse? Exercise getting harder? Examine your diet. New

research published online in The FASEB Journal (http://www.fasebj.org) showed

that in less than 10 days of eating a high-fat diet, rats had a decreased

ability to exercise and experienced significant short-term memory loss. These

results show an important link between what we eat, how we think, and how our

bodies perform.

" Western diets are typically high in fat and are associated with long-term

complications, such as obesity, diabetes, and heart failure, yet the short-term

consequences of such diets have been given relatively little attention, " said

Murray, co-author of the study and currently at the University of

Cambridge in the United Kingdom. " We hope that the findings of our study will

help people to think seriously about reducing the fat content of their daily

food intake to the immediate benefit of their general health, well-being, and

alertness. "

Murray and colleagues studied rats fed a low-fat diet (7.5 percent of calories

as fat) and rats fed a high-fat diet (55 percent of calories as fat). The

researchers discovered that the muscles of the rats eating the high-fat diet for

four days were less able to use oxygen to make the energy needed to exercise,

causing their hearts to worker harder—and increase in size. After nine days on a

high-fat diet, the rats took longer to complete a maze and made more mistakes in

the process than their low-fat-diet counterparts. Researchers then investigated

the cellular causes of these problems, particularly in the mitochondria of

muscle cells. They found increased levels of a protein called uncoupling protein

3, which made them less efficient at using oxygen needed to make the energy

required for running.

" It's nothing short of a high-fat hangover, " said Gerald Weissmann, M.D.,

Editor-in-Chief of The FASEB Journal. " A long weekend spent eating hotdogs,

French fries, and pizza in Orlando might be a great treat for our taste buds,

but they might send our muscles and brains out to lunch. "

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