Re: B6 - Severe sensorimotor neuropathy after intake of highest dosages of vitam

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Neuromuscul Disord. 2008 Feb;18(2):156-8.

Severe sensorimotor neuropathy after intake of highest dosages of

vitamin B6.

Gdynia HJ, Müller T, Sperfeld AD, Kühnlein P, Otto M, Kassubek J,

Ludolph AC.

Department of Neurology, University of Ulm, Oberer Eselsberg 45,

89081 Ulm, Germany.

We illustrate a white caucasian patient with a severe sensorimotor

neuropathy due to vitamin B6 hypervitaminosis. The patient used the

pendulum to calculate his daily metabolic demands and ingested 9.6g

pyridoxine/day. To our knowledge, this is the highest dosage of

vitamin B6 administered to humans over prolonged periods of time ever

reported in the medical literature. The unique aspect of this case is

the muscle weakness and motor findings on electrophysiological

testing in what is suggested by the literature to be a pure sensory

neuronopathy.