Chronic Meningitis

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Etiology and Management of Chronic Meningitis

There are numerous causes of chronic meningitis, including infectious,

inflammatory, neoplastic, and toxic exposures. Infectious causes are bacteria,

mycobacteria, fungi, viruses, and parasites. Noninfectious causes include, but

are not limited to, sarcoidosis, Behçet's disease (BD), Wegener's granulomatosis

(WG), systemic lupus erythematosus (SLE), medications, and neoplasms.1,6,7 In up

to one-third of patients with chronic meningitis, no cause is found.

http://www.uspharmacist.com/content/t/neurology/c/18842/dnnprintmode/true/?skins\

rc=[l]skins/usp2008/pageprint & containersrc=[l]containers/usp2008/simple

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Hypoxia, barrier disruption, and necrosis of the white matter

Failure of repair of early barrier disruption may also evolve into persistent

barrier incompetence.

hypoxia is a crucial stimulus for vascular endothelial growth factor

(VEGF)––also known as vascular permeability factor––which is known to mediate

increased permeability in a wide range of tissues including the CNS

http://www.biology-online.org/articles/mechanisms_radiation_injury_central/hypox\

ia_barrier_disruption_necrosis.html

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Axonal injury, a neglected cause of CNS damage in bacterial meningitis

http://www.neurology.org/cgi/content/abstract/62/3/509