penicillin, yeast infection, thrush

[Guest guest]

well, I'm just a wanabe researcher with a brain injury but heres how I always

thought the WDB caused yeast infections.

many woman know and have experienced yeast infections with antibiotic use. the

antibiotic penicillin is made from penicillium notatum, a mold that can be in

WDB's.

anyway, it kind of seemed logical to me that if takeing the antibiotic

penicillin gave me a yeast infection why wouldn't exposure to the actual mold

itself not do the same.

so anyway with my IgE and IgG to penicillium notatum and candida albicans, I

felt even more so that it was a possablity.

one of the first things I read up on was the discovery of penicillin and you can

find references to it being basicly said to be the mycotoxins derived from

penicillium notatum.

so anyway, topic got around to yeast vaginitis the other day so I did a little

looking,

thought this was interesting. there was a study where the mycotoxin

Gliotoxin was found from 3 woman who had severe yeast vaginitis so it was

thought that candida albicans produced these mycotoxins. ?

below is two studies, one in the 90's that said Gliotoxin was found to be

produced by candida, than in 2007 a study failed to find Gliotoxin produced by

candida. ?

kindof interesting aint it? how it all seems to tie together.

seems to me as one example of why WDB cause yeast infections and thrush. of

corse probably many other mycotoxins disrupt the bacterial and yeast balance.

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Gliotoxin, originally isolated from Gliocladium fimbriatu, is an antibiotic

produced by molds Aspergillus, Trichoderma, and Penicillium. Gliotoxin possesses

immunosuppressive properties as it may suppress and cause apoptosis in certain

types of cells of the immune system.

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Penicillium chrysogenum (also known as P. notatum),

http://www.phadia.com/es/Alergenos/ImmunoCAP-Allergens/Molds-and-other-Microorga\

nisms/Allergens/Penicillium-glabrum/

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Mycotoxins are even made by these yeast inside of the body. In one study,

scientists isolated a mycotoxin called gliotoxin (which suppresses our immune

system) from three women who had severe symptoms of yeast vaginitis!11 " Simple "

yeast infections should be looked at as more serious, system-wide problems that

need to be quickly and completely (i.e., treat the gut, too) eliminated

http://www.thinkfungus.com/public/84print.cfm

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Mycopathologia. 1991

Clinical isolates of yeast produce a gliotoxin-like substance.

Abstract

Candida infections are major causes of morbidity in compromised human hosts, but

our understanding of the virulence of Candida remains incomplete. The

possibility that toxic fungal metabolites belonging to the chemical class

epipolythiodioxopiperzine (ETP), which are reported to possess immunomodulating

and antiphagocytic properties may be produced by Candida species was

investigated. Reversed phase HPLC analysis of flash evaporated chloroform

extracts of 7 day cultures of clinical Candida isolates grown in Minimal

Essential Medium (MEM) with 5% fetal calf serum revealed the presence of a

compound which eluted at the same time as the ETP, gliotoxin. Of 50 strains of

yeast tested, 32 produced this gliotoxin-like material. This material was tested

for other properties of ETP type toxins including the presence of mercaptans

(Ellman reaction), ultraviolet absorbance spectrum and antibacterial activity

against Micrococcus lutea. These tests revealed gliotoxin-like material from

yeast cultures to be similar to commercially supplied gliotoxin. This represents

the first report of the presence of ETP-like compounds in yeast and raises the

possibility that ETP's may contribute to the virulence of the organism

http://www.ncbi.nlm.nih.gov/pubmed/1724551

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however than :

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FEMS Yeast Res. 2007

Candida species fail to produce the immunosuppressive secondary metabolite

gliotoxin in vitro.

Institute for Medical Microbiology and Hygiene, Faculty for Clinical Medicine

Mannheim of the University Heidelberg, Mannheim, Germany.

claudio.kupfahl@...

Abstract

Yeasts of the genus Candida are a major cause of morbidity and mortality in

immunocompromised patients. Despite new insights in recent years, the

pathogenesis of Candida infection is still incompletely understood. Previous

studies have suggested that gliotoxin, a secondary fungal metabolite with

well-known immunosuppressive effects, is produced by various species of the

genus Candida, and a possible role of gliotoxin as a virulence factor of C.

albicans has also been discussed. However, until now, no definitive evidence has

been provided that members of the genus Candida are able to produce gliotoxin.

To clarify this question, we tested a total of 100 clinical isolates of C.

albicans, C. glabrata, C. tropicalis, C. krusei and C. parapsilosis for

gliotoxin production using a highly sensitive HPLC protocol, and, for selected

isolates, confirmed our findings by tandem MS. This approach did not detect

intracellular or extracellular gliotoxin production by any of the isolates

examined, although various culture conditions were applied. Therefore, in

contrast to previous studies, our data strongly suggest that at least the

Candida species investigated in this study are not able to produce the secondary

metabolite gliotoxin

http://www.ncbi.nlm.nih.gov/pubmed/17537180

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The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode

of action, functions and biosynthesis

http://mic.sgmjournals.org/cgi/content/full/151/4/1021

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