Re: IL-17/Th17 in anti-fungal immunity: What's new?

July 3, 2010

between these two articles it sounds like really, the worse the exposure the

more tissue damage, chance of fungal infection, and even chance of allergy and

autoimmunity. I hadn't read up on TH17 lately,

I think this is pretty important information.

this one also refers to fungal infection.

IL-17 and anti-bacterial immunity: Protection versus tissue damage

http://www3.interscience.wiley.com/cgi-bin/fulltext/122255032/HTMLSTART

Viewpoints on Th17/IL-17

IL-17 and anti-bacterial immunity: Protection versus tissue damage

M. *

Trudeau Institute, NY, USA

email: M. (acooper@...)

*Correspondence to M. , Trudeau Institute, 154 Algonquin Avenue,

Saranac Lake, NY 12983, USA Fax: +1-518-891-5126

Funded by:

NIH; Grant Number: AI 46535, AI69121, AI-67723

Trudeau Institute

Keywords

Bacteria • IL-17 • Immunity • Inflammation

Abstract

IL-17 can impact health in a variety of ways. It is protective for some

pathogens but it is also associated with tissue damaging inflammation. By

examining the role of IL-17 in a variety of bacterial infections the mechanisms

by which this cytokine mediates both protection and damage can be dissected. A

key element in understanding the role of this cytokine is determining where and

when it is acting. Dissecting its essential protective role from its

immunopathologic role will allow for improved intervention in both acute and

chronic disease.

both here

http://www3.interscience.wiley.com/journal/25061/home/virtual_issue__th17.htm

>

> IL-17/Th17 in anti-fungal immunity: What's new?

http://www3.interscience.wiley.com/cgibin/fulltext/122255031/HTMLSTART

>

July 4, 2010

still, it points to DC function in the role of TH17 function.

which plays in with the danger model. seems most cells are muti-taskers

and maybe it's the poison that well deturmine exactually what happens.

our first line defences difenitly play a major role on outcome.

one of these articles stated that fungi can affect compliment.

also theres a statement talking about how fungi has evolved to gain control over

some immune functions to help itself.

DC's function in both innate and aquired immunity and cross talk.

mast cells and DC cells present antigens.

and this is about immune functions as a result of exposure.

mast cells present ag's to MHC 1, so really there are possabilities

of non-presentation to MHC and this would make bad HLA genictics not important,

but I dont think it's really even that important from what I understand it's the

mycotoxins that are presented as antigens to the MHC CLASS 1, with the HLA bad

genetic involvement and maybe mycotoxins

and not being able to quickly rid them, does the damage that they are pretty

well known to do, thats a given. however if you look at everything that can be

involved in a WDB exposure, mycotoxins are not the only thing we are dealing

with. now I dont know how or if or the extent in which mold and it's mycotoxins

can be seperated, really.

than theres other toxins involved here.

but if it's possable to be exposed to only mold without mycotoxins,

these articles clearly point to some very damageing health problems related to

what they refer to as fungi. and when it comes to immune effects and chronic

exposures of allergens,pathogens or toxins it causes alot of stress on the

immune system and by logic, the more involved the more confused our immune

systems may become, or streseed or bounceing back and forth between what one

type of ag may demand out of immune system and another type may demand.

I think it well be a mericle if theres ever any clear cut answers here.

it makes my head spin, basically and thats why I quit trying to find answers

here anyway. theres just to much going on there, to many possabilitys of immune

disfunctions than you throw in immune supression

which not only mycotoxins and I'm sure other toxins can cause to at least some

of our immune functions, but even certain disfunctions with our own cells can

supress other functions with our cells.

one thing that should be becomeing very clear to medical science is that

environment toxins and even non-toxic pathogens(which can cause

autoimmunity,self attacking self, which is toxic to our systems)

and even a hudge dose to allergens and/or chronic exposure for some people at

even lower doses can cause the immune system to become disfunctional, and can

lead to disease.

thruth is for me, that I fell like I did experience to tottally different WDB

exposures and one may have very possabily been more so to mycotoxins than the

other, if thats possable. and I think to a extent it is. I personally think that

VOC's play a hudge role in the chemiccal sensitivity, and if it's possable in a

very high moisture setting that you are exposed to higher amounts of mold and

VOC'S and maybe less mycotoxins, than that would have been my second exposure

that caused CS and allergies to molds and alot of tissue and organ damage and

very possabily fungal miningitis.

I would love to see some studies done in to different environments, one with a

wetting /drying action and one with a constant high moisture

environment to see if there is a difference in mycotoxin exposure.

so anyway, the distraction was worth reading up on TH17,ECT.

back to my other project. HAPPY 4TH OF JULY EVERYONE.

this is a good read on mast cell functions

http://www3.interscience.wiley.com/cgi-bin/fulltext/123563063/HTMLSTART

Along with DC, mast cells are well positioned to be one of the first cells of

the immune system to interact with environmental Ag, environmentally derived

toxins, or invading pathogens

But one thing is certain: evolution did not give us mast cells so that we can

eat a peanut and die.

Answering these questions will take time. It is already clear, however, that

mast cells have a much larger spectrum of potential roles in health and disease

than was thought only a short time ago, when interest focused mainly on their

role as effector cells in IgE-associated responses. Indeed, mast cells are

increasingly viewed as versatile effector and immunoregulatory cells that occupy

a critical position at the interface of innate and acquired immunity, where,

depending on circumstances that remain to be fully understood, mast cells may

either help to sustain and restore health or contribute to disease.

September 5, 2010

Wow.. Jeanine.. this is great info.. thank you so much. My brain is inflammed

again and mush right now and Im feeling shaky, so need time to grasp this.

Ive got to find a way to address my sinus situation which might be due to what

you are describing here.. damage for sure. Its starting to scare me.. either I

am noticing it more and realizing what it is or its unmasking since the stachy

colony was removed.

I can usually handle the scientific info with some help...

Quick question.. the HLA types dont get rid of fast enough or not at all? I hope

shoemakers new book goes into some detail on this. If its in Mold Warriors, I

cant find.. I have problems following mold warriors anyway. I need bullet points

and graphics. More orgenization.

Thanks so much for the links and your analysis. Yeah. it does make my head spin

too. An overall idea of what is going on is helpful though... I think..

Robin

>

> still, it points to DC function in the role of TH17 function.

> which plays in with the danger model. seems most cells are muti-taskers

> and maybe it's the poison that well deturmine exactually what happens.

> our first line defences difenitly play a major role on outcome.

> one of these articles stated that fungi can affect compliment.

> also theres a statement talking about how fungi has evolved to gain control

over some immune functions to help itself.

> DC's function in both innate and aquired immunity and cross talk.

> mast cells and DC cells present antigens.

> and this is about immune functions as a result of exposure.

> mast cells present ag's to MHC 1, so really there are possabilities

> of non-presentation to MHC and this would make bad HLA genictics not

important, but I dont think it's really even that important from what I

understand it's the mycotoxins that are presented as antigens to the MHC CLASS

1, with the HLA bad genetic involvement and maybe mycotoxins

> and not being able to quickly rid them, does the damage that they are pretty

well known to do, thats a given. however if you look at everything that can be

involved in a WDB exposure, mycotoxins are not the only thing we are dealing

with. now I dont know how or if or the extent in which mold and it's mycotoxins

can be seperated, really.

> than theres other toxins involved here.

> but if it's possable to be exposed to only mold without mycotoxins,

> these articles clearly point to some very damageing health problems related to

what they refer to as fungi. and when it comes to immune effects and chronic

exposures of allergens,pathogens or toxins it causes alot of stress on the

immune system and by logic, the more involved the more confused our immune

systems may become, or streseed or bounceing back and forth between what one

type of ag may demand out of immune system and another type may demand.

> I think it well be a mericle if theres ever any clear cut answers here.

> it makes my head spin, basically and thats why I quit trying to find answers

here anyway. theres just to much going on there, to many possabilitys of immune

disfunctions than you throw in immune supression

> which not only mycotoxins and I'm sure other toxins can cause to at least some

of our immune functions, but even certain disfunctions with our own cells can

supress other functions with our cells.

> one thing that should be becomeing very clear to medical science is

September 6, 2010

Robin, those where basicly some thoughts, me trying to make sence of it all, you

might come away with a different view. yes, the immune system is a tough one to

research. all the cascadeing effects just boggle the brain. I think the HLA's

bad genetics just add to our tottal toxic load, not elimate our detoxing

abilities completely. if I understand right theres other ways of antigens

getting reconized, theres info. that some might not be getting reconized by

other processes, and theres other detoxing routes besides the liver.

I understand how you have a need to understand, I always have too, but the

immune system just blows me away. theres like different effects from bacterial

exposure, fungi, parasites, and geez, it just leaves me thinking that if you

dont know exactly whats happened to your immune system, how can you possably

deside on what may help you or not. thats where getting to some of our experts

comes in and getting some labs done.

>

> Wow.. Jeanine.. this is great info.. thank you so much. My brain is inflammed

again and mush right now and Im feeling shaky, so need time to grasp this.

>

> Ive got to find a way to address my sinus situation which might be due to what

you are describing here.. damage for sure. Its starting to scare me.. either I

am noticing it more and realizing what it is or its unmasking since the stachy

colony was removed.

>

> I can usually handle the scientific info with some help...

>

> Quick question.. the HLA types dont get rid of fast enough or not at all? I

hope shoemakers new book goes into some detail on this. If its in Mold Warriors,

I cant find.. I have problems following mold warriors anyway. I need bullet

points and graphics. More orgenization.

>

> Thanks so much for the links and your analysis. Yeah. it does make my head

spin too. An overall idea of what is going on is helpful though... I think..

>

> Robin

September 6, 2010

Thank you, Jeanine. Need to know is part feeling in control but the problem is

the info is as you say.. not always very controllable, orderly etc.. I also just

do have a need to know and a desire to comprehend so I can make decisions..

again the crazy info as you delve makes that more complicated and yet also

fascinating.. crazy.

Other detox routes .. the idea of it.. is helpful. My husband (mentioning again)

has had many exposures, one of the " dreadeds " and lyme and (again) he is fine.

Not sure what is going on there.

Just bringing the overall toxic load down.. that concept it helpful.. even if

not mold toxins or endotoxins addressing methylation (including glutathione

depletion), KPU/HPU, metals, chemical poisoning, etc.

I realize that in the end of all the research we do what we know which is to

address the inflammation, detox, address fungus and other bugs .. not clear on

immune system any more..

First.. get out of here..

The CFS retrovirus is going to shed some light for some of us.. lots of

inflammatory markers lighting up with this one. I ahve alist in my files if you

are interested.

Thanks..

Robin

>

> Robin, those where basicly some thoughts, me trying to make sence of it all,

you might come away with a different view. yes, the immune system is a tough one

to research. all the cascadeing effects just boggle the brain. I think the HLA's

bad genetics just add to our tottal toxic load, not elimate our detoxing

abilities completely. if I understand right theres other ways of antigens

getting reconized, theres info. that some might not be getting reconized by

other processes, and theres other detoxing routes besides the liver.

> I understand how you have a need to understand, I always have too, but the

immune system just blows me away. theres like different effects from bacterial

exposure, fungi, parasites, and geez, it just leaves me thinking that if you

dont know exactly whats happened to your immune system, how can you possably

deside on what may help you or not. thats where getting to some of our experts

comes in and getting some labs done.

>

September 6, 2010

Thanks Robin, but no, I dont believe that type of chronic fatique goes with WDB

exposures, CFS, I just get fatigue with re-exposures and/or over exsertion, and

general days of just felling malise maybe sometimes just tied to the weather,

and even sometimes stomach related. I think being low in b12 and maybe vit. D

may contribute to energy loss. right now Im doing the antifungal nasal spray and

I'm not felling to great for the last several days, might be due to die off.

>

> Thank you, Jeanine. Need to know is part feeling in control but the problem is

the info is as you say.. not always very controllable, orderly etc.. I also just

do have a need to know and a desire to comprehend so I can make decisions..

again the crazy info as you delve makes that more complicated and yet also

fascinating.. crazy.

>

September 7, 2010

Yes like the lyphatic system (detoxification )

Â

The Lymphatic System

The lymphatic system is one of the most important systems in our body. Proper

functioning of the lymphatic system is critical to our body's ability to

detoxify, nourish and regenerate tissue, filter out metabolic waste and

inorganic material, and maintain a healthy immune system.

Â

http://www.lilipoh.com/articles/special_issues/CancerIssue/BasicsofLymphatic.asp\

x

Â

The Lymphatic System PDF

Â

http://classvideos.net/anatomy/pdf/lymph-pdf.pdfÂ

God Bless !!

dragonflymcs

Mayleen

________________________________

From: osisposis <jeaninem660@...>

Sent: Mon, September 6, 2010 9:47:17 AM

Subject: [] Re: IL-17/Th17 in anti-fungal immunity: What's new?