Guest guest Posted February 14, 2010 Report Share Posted February 14, 2010 Hi everyone. Was just reading about an autoimmune disorder called Sgrens syndrome (sigrens?) its a lack of moisture in tears, mouth etc. has anyone heard of this and could this be caused by toxic mold?? thanx Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 Hi, I've been experiencing some problems with dry eyes and mouth, and someone on this list suggested that I look into Sjogren's Syndrome. I mentioned it to my eye doctor and she recommended that I see a rheumatologist. I did so and now have a prescription for Sargen, a medication that is supposed to increase bodily moisture. There are simple blood tests for Sjogren's Syndrome called anti-SSA and anti-SSB. Hope this helps a little. Joanne > > Hi everyone. Was just reading about an autoimmune disorder called Sgrens syndrome (sigrens?) its a lack of moisture in tears, mouth etc. has anyone heard of this and could this be caused by toxic mold?? thanx > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 Sogren's syndrome is more than just dry eyes, mouth, etc. It occurs most frequently in families that have a history of autoimmune disorders. The disease process can involve other organs of the body and include vasculitis, G.I. tract and skin. Can exposure to the biocontaminants lead to autoimmune diseases? Dr. Gray and I have published on autoimmunity and exposure to molds/bacteria contaminants in indoor environment. Elevation of autoantibodies is present, particularly ANA and antimyelin. I believe Dr. Shoemaker has also alluded to this. However, more work needs to be done in this area. Jack-Dwayne: Thrasher, Ph.D. Toxicologist/Immunotoxicologist/Fetaltoxicologist www.drthrasher.org toxicologist1@... Off: 916-745-4703 Cell: 575-937-1150 L. Crawley, M.ED., LADC Trauma Specialist sandracrawley@... 916-745-4703 - Off 775-309-3994 - Cell This message and any attachments forwarded with it is to be considered privileged and confidential. The forwarding or redistribution of this message (and any attachments) without my prior written consent is strictly prohibited and may violate privacy laws. Once the intended purpose of this message has been served, please destroy the original message contents. If you have received this message in error, please reply immediately to advise the sender of the miscommunication and then delete the message and any copies you have printed. Thank you in advance for your compliance. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2010 Report Share Posted February 15, 2010 Jack, where can we see your published work on this subject? thanks, sue v. > >Can exposure to the biocontaminants lead to autoimmune diseases? Dr. >Gray and I have published on autoimmunity and exposure to molds/bacteria >contaminants in indoor environment. Elevation of autoantibodies is >present, particularly ANA and antimyelin. I believe Dr. Shoemaker has >also alluded to this. However, more work needs to be done in this area. > >Jack-Dwayne: Thrasher, Ph.D. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 16, 2010 Report Share Posted February 16, 2010 Send me an email and I will send you some reprints. Toxic exposure have been known for years to lead to autoimmune disorders, especially lupus. Jack-Dwayne: Thrasher, Ph.D. Toxicologist/Immunotoxicologist/Fetaltoxicologist www.drthrasher.org toxicologist1@... Off: 916-745-4703 Cell: 575-937-1150 L. Crawley, M.ED., LADC Trauma Specialist sandracrawley@... 916-745-4703 - Off 775-309-3994 - Cell This message and any attachments forwarded with it is to be considered privileged and confidential. The forwarding or redistribution of this message (and any attachments) without my prior written consent is strictly prohibited and may violate privacy laws. Once the intended purpose of this message has been served, please destroy the original message contents. If you have received this message in error, please reply immediately to advise the sender of the miscommunication and then delete the message and any copies you have printed. Thank you in advance for your compliance. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 16, 2010 Report Share Posted February 16, 2010 According to my Lyme doctor it can also be caused by Lyme since it likes to live in the mucous linning of our bodies. It is not uncommon for Lymies to have that. Lyme mimics many diseases and conditions. cathy > > > > Hi everyone. Was just reading about an autoimmune disorder called Sgrens syndrome (sigrens?) its a lack of moisture in tears, mouth etc. has anyone heard of this and could this be caused by toxic mold?? thanx > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 17, 2010 Report Share Posted February 17, 2010 Dr. Thrasher, Thank you for adding your comments. My ophthalmologist, Dr. andra Kostik, tried several methods to resolve my dry eye problem (which is causing blurriness and could cause me to lose my eyesight eventually) before suggesting that I visit the rheumatologist. I am using artificial tears four times per day and also Restasis twice per day. I had temporary plugs inserted, too, and decided last month to visit the rheumatologist before having these plugs inserted permanently. The rheumatologist, Dr. Tsai, has an exemplary background and operates an Arthritis, Allergy, and Autoimmune Disease Institute in Florida. He does not yet have the results of my blood test but told me to go ahead and try the medication Sargen for three months to see if it helps my eyes; he said Sargen might help even if I don't have Sjogren's Syndrome. The reason I think I might have an auto-immune disease is because my T-cell count was out of range (too low) after exposure to high amounts of stachybotrys and aspergillus over a ten-year period. The T-cell test was originally conducted by Dr. Johanning, a well-known researcher and speaker in the toxic mold field. I hope this additional information helps you to see that I wasn't too lightly suggesting to another member of this group that they might wish to try this medication to combat a lack of body moisture. I'm certainly not a doctor, but from what I've been told, it might be worthwhile to at least check on Sargen with one's own physician. Thanks again for sharing your expertise. Joanne --- In , " Jack Thrasher, Ph.D. " <toxicologist1@...> wrote: > > Sogren's syndrome is more than just dry eyes, mouth, etc. It occurs most frequently in families that have a history of autoimmune disorders. The disease process can involve other organs of the body and include vasculitis, G.I. tract and skin. > > Can exposure to the biocontaminants lead to autoimmune diseases? Dr. Gray and I have published on autoimmunity and exposure to molds/bacteria contaminants in indoor environment. Elevation of autoantibodies is present, particularly ANA and antimyelin. I believe Dr. Shoemaker has also alluded to this. However, more work needs to be done in this area. > > Jack-Dwayne: Thrasher, Ph.D. > Toxicologist/Immunotoxicologist/Fetaltoxicologist > www.drthrasher.org > toxicologist1@... > Off: 916-745-4703 > Cell: 575-937-1150 > > > L. Crawley, M.ED., LADC > Trauma Specialist > sandracrawley@... > 916-745-4703 - Off > 775-309-3994 - Cell > > > > > This message and any attachments forwarded with it is to be considered privileged and confidential. The forwarding or redistribution of this message (and any attachments) without my prior written consent is strictly prohibited and may violate privacy laws. Once the intended purpose of this message has been served, please destroy the original message contents. If you have received this message in error, please reply immediately to advise the sender of the miscommunication and then delete the message and any copies you have printed. Thank you in advance for your compliance. > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 17, 2010 Report Share Posted February 17, 2010 Joeanne, I'm real interested in hearing more of your dryeye symptoms! I too was told mine were dry n had the restasis and the plugs....none worked. my neuro-opth. couldn't explain y I had pain 24 hrs and how I get migraines from 5word when I read. Can u look at a computer? Jill On Wed Feb 17th, 2010 7:43 AM EST mello5757 wrote: >Dr. Thrasher, > >Thank you for adding your comments. > >My ophthalmologist, Dr. andra Kostik, tried several methods to resolve my dry eye problem (which is causing blurriness and could cause me to lose my eyesight eventually) before suggesting that I visit the rheumatologist. I am using artificial tears four times per day and also Restasis twice per day. I had temporary plugs inserted, too, and decided last month to visit the rheumatologist before having these plugs inserted permanently. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2010 Report Share Posted February 18, 2010 Joanne: I have a few comments on this subject matter. You said that your T cell counts were low. This may indicate immune suppression. There is information that gliotoxin, mycophenolic acid, trichothecenes, aflatoxins and ochratoxin are immune suppressive mycotoxins. The have different modes of action to cause this. For example, mycophenolic acid (Penicillium species) inhibits the incorporation of purines into DNA of T and B cells, reducing the numbers. MPA is commonly used in kidney transplant patients. Trichothecenes cause the immune suppression by inhibiting protein synthesis an indirectly affecting DNA and RNA synthesis. I suggest that you be tested for mycotoxins in your early morning urine and nasal secretions. Examples, Brasel et al identified trichothecenes in the plasma of individuals exposed to Stachybotrys; Hooper has demonstrated mycotoxins in tissues and urine of individuals exposed to damp indoor spaces; has detected gliotoxin in plasma and lung secretions of cancer patients with aspergillums. Your dry eyes and mouth may or may not be Sogren's. You need to have specific testing for Sogren autoantibodies to make this determination. You may also have an infectious process from Actinomycetes. This should be checked also. If you want more information on this, please email me. Jack-Dwayne: Thrasher, Ph.D. Toxicologist/Immunotoxicologist/Fetaltoxicologist www.drthrasher.org toxicologist1@... Off: 916-745-4703 Cell: 575-937-1150 L. Crawley, M.ED., LADC Trauma Specialist sandracrawley@... 916-745-4703 - Off 775-309-3994 - Cell This message and any attachments forwarded with it is to be considered privileged and confidential. The forwarding or redistribution of this message (and any attachments) without my prior written consent is strictly prohibited and may violate privacy laws. Once the intended purpose of this message has been served, please destroy the original message contents. If you have received this message in error, please reply immediately to advise the sender of the miscommunication and then delete the message and any copies you have printed. Thank you in advance for your compliance. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2010 Report Share Posted February 18, 2010 Would this cause your white blood cell count to be low, or even normal when you are sick and should be high in non-toxic person? My internist, when I was feeling sick in the past -when I was exposed to mold, would do a cbc and then say I couldn't have an infection because my white blood cell count was not high. --- In , " Jack Thrasher, Ph.D. " <toxicologist1@...> wrote: > > Joanne: I have a few comments on this subject matter. You said that your T cell counts were low. This may indicate immune suppression. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2010 Report Share Posted February 19, 2010 Mycotoxins and other toxins have interesting interactions. It is documented that tricothecenes can cause neutropenias. There is also information in the literature that aflatoxins and ochratoxins can do the same. I suspect that gliotoxin may also be capable of causing neutropenia. Finally, mycophenolic acid used in transplant patients will do it also. From what I can gather from the literature, the bone marrow in these people is normal. Apparently the toxins cause apoptosis of the mature white blood cells and/or prevent them from entering the circulation. Here is the problem. Doctors are not taught this in the medical school curriculum. Therefore, they are ignorant of the adverse affects of these toxins. There is increasing evidence that at least two species of Mycobacterium produce a very cytotoxic chemical, mycolactone. It is also immune suppressive. Jack-Dwayne: Thrasher, Ph.D. Toxicologist/Immunotoxicologist/Fetaltoxicologist www.drthrasher.org toxicologist1@... Off: 916-745-4703 Cell: 575-937-1150 L. Crawley, M.ED., LADC Trauma Specialist sandracrawley@... 916-745-4703 - Off 775-309-3994 - Cell This message and any attachments forwarded with it is to be considered privileged and confidential. The forwarding or redistribution of this message (and any attachments) without my prior written consent is strictly prohibited and may violate privacy laws. Once the intended purpose of this message has been served, please destroy the original message contents. If you have received this message in error, please reply immediately to advise the sender of the miscommunication and then delete the message and any copies you have printed. Thank you in advance for your compliance. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 20, 2010 Report Share Posted February 20, 2010 Dr. Thrasher, About three years ago my eye doctor informed me that I had dry eyes. I didn't pay much attention but the dry eyes have not gone away and I'm going to be tested for this disease the next time I go and after already being diagnosed with two other autoimmune disorders I'm pretty sure I have this one as well. So I was wondering if it's related to toxins how do I get rid of them? I'm so tired of getting diagnosed with autoimmune disorders and would like to know if there is a way to get rid of these toxins or do we have to live with them for the rest of our lives? Thanks. --- In , " Jack Thrasher, Ph.D. " <toxicologist1@...> wrote: > > Mycotoxins and other toxins have interesting interactions. > > There is increasing evidence that at least two species of Mycobacterium produce a very cytotoxic chemical, mycolactone. It is also immune suppressive. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 20, 2010 Report Share Posted February 20, 2010 Would tenuazonic acid from alternaria tenuis do the same? http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10704 2001 Jul-Aug;29(4):492-7. Analysis of toxic effects of Alternaria toxins on esophagus of mice by light and electron microscopy. Yekeler H, Bitmiþ K, Ozçelik N, Doymaz MZ, Calta M. Department of Pathology Medical School, Firat University, Elazið, Turkey. doymaz@... In this study, the possible toxic effects of Alternariol Methyl Ether (AME) and Tenuazonic Acid (TeA) produced by Alternaria species on esophagus of mice were investigated by using light and electron microscopy techniques. Mice were orally fed daily with AME or TeA for 10 months and at the end of this period, the effects of these chemicals on the esophageal mucosa were determined. By light microscopic examination, moderate and severe dysplasia characterized by loss of polarity, nuclear pleomorphism, and hyperchromasia were observed in TeA-treated animals. Electron-microscopic examination of TeA-treated mucosal epithelial cells revealed pyknosis in some nuclei, granulation and increase in chromatin mass, irregularities in the nuclear contours, vacuolization in nucleoplasms. and marked pleomorphism in the nuclei. In conclusion, our results suggested that TeA has higher toxicity as evidenced by dysplastic transformation. PMID: 11560255 [PubMed - indexed for MEDLINE] 1992;147(3-4):207-13. [Toxin-producing ability of molds of the genus Alternaria] [Article in German] Müller M. Institut für Futterproduktion Pualinenaue, Deutschland. The ability to produce the Alternaria mycotoxins alternariol (AOH), alternariol monomethyl ether (AME) and altenuene (ALT) were studied on 87 Alternaria strains. 50 isolates were studied to produce tenuazonic acid (TeA). The strains were isolated from CCM-maize and stored hay. They were cultured under optimum conditions and analysed by various chromatographic methods for the 4 mycotoxins. All Alternaria strains studied produced AME and TeA, 77 per cent also AOH. A production of ALT was detected only in 18 per cent of the isolates. The concentrations of toxins produced were 0.08-482 (162) ppm for AME, 0.05-1862 (121) ppm for AOH, 0.1-34 (9.1) ppm for ALT and 0.02-42 (11.3) mg/100 ml liquid medium for TeA. The species Alternaria alternata (Fries) Keissler and Alternaria tenuissima (Kunze:Fr.) Wiltshire produced the greatest amounts of all mycotoxins studied. PMID: 1609553 [PubMed - indexed for MEDLINE] ------------------ --- In , " Jack Thrasher, Ph.D. " <toxicologist1@...> wrote: > > Mycotoxins and other toxins have interesting interactions. It is documented that tricothecenes can cause neutropenias. There is also information in the literature that aflatoxins and ochratoxins can do the same. I suspect that gliotoxin may also be capable of causing neutropenia. Finally, mycophenolic acid used in transplant patients will do it also. From what I can gather from the literature, the bone marrow in these people is normal. Apparently the toxins cause apoptosis of the mature white blood cells and/or prevent them from entering the circulation. > > Here is the problem. Doctors are not taught this in the medical school curriculum. Therefore, they are ignorant of the adverse affects of these toxins. > > There is increasing evidence that at least two species of Mycobacterium produce a very cytotoxic chemical, mycolactone. It is also immune suppressive. > > Jack-Dwayne: Thrasher, Ph.D. > Toxicologist/Immunotoxicologist/Fetaltoxicologist > www.drthrasher.org > toxicologist1@... > Off: 916-745-4703 > Cell: 575-937-1150 > > > L. Crawley, M.ED., LADC > Trauma Specialist > sandracrawley@... > 916-745-4703 - Off > 775-309-3994 - Cell > > > > > This message and any attachments forwarded with it is to be considered privileged and confidential. The forwarding or redistribution of this message (and any attachments) without my prior written consent is strictly prohibited and may violate privacy laws. Once the intended purpose of this message has been served, please destroy the original message contents. If you have received this message in error, please reply immediately to advise the sender of the miscommunication and then delete the message and any copies you have printed. Thank you in advance for your compliance. > > > > Quote Link to comment Share on other sites More sharing options...
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