NON-ACID REFLUX, interesting,GABA again, (liver,brain)

[Guest guest]

I pretty possitive what we suffer is non-acid reflux, or lack of acid reflux. or

me anyway. thats why the diet pepsi helps, the acid effect.

non-acid reflux goes with bile in the stomach.

Non-acid Gastroesophageal Reflux

Pharmacological options

for non-acid reflux include inhibition of

transient lower esophageal sphincter

relaxations (TLESRs) by agents such as

the GABA B agonist baclofen, which has

been shown to decrease TLESRs, nonacid

reflux, and related symptoms (12).

I start patients on a small dose (5 mg

PO t.i.d.), with a gradual dose increase

of 5 mg every 4 days until 20 mg t.i.d.

is reached. An alternative is to prescribe

10 mg PO t.i.d. and assess the efficacy

and side effects before further dosing

adjustment. Side effects such as nausea,

sleepiness, or dizziness are fairly

frequent and are unacceptable in some

patients. It is hoped that new, more

tolerable GABAB agonists will become

available in the future.

http://www.sovegastro.com/pdf/REFLUJO%20NO%20ACIDO.pdf

GABA

The yin-yang relationship between the glutamatergic excitatory and GABAergic

inhibitory systems is played out on the tightrope of a delicate balance, and

imbalances between them lead to serious disorders

http://www.scholarpedia.org/article/GABA#GABA_and_diseases_of_the_CNS