Re: new on-set asthma, damp mouldy indoor

[Guest guest]

Note that the authors conclude that IgE is rare.

[] new on-set asthma, damp mouldy indoor

Int Arch Occup Environ Health. 2010 Feb 3. [Epub ahead of print]

New-onset adult asthma in relation to damp and moldy workplaces.

Karvala K, Toskala E, Luukkonen R, Lappalainen S, Uitti J, Nordman H.

Occupational Medicine Team, Finnish Institute of Occupational Health (FIOH),

Topeliuksenkatu 41 a A, 00250, Helsinki, Finland, kirsi.karvala@....

Abstract

OBJECTIVE: Damp and moldy indoor environments aggravate pre-existing asthma.

Recent meta-analyses suggest that exposure to such environments may also

induce

new-onset asthma. We assessed the probability of molds being the cause of

asthma

in a patient series examined because of respiratory symptoms in relation to

workplace dampness and molds.

METHODS: Altogether 694 such patients had been clinically assessed between

1995

and 2004. According to their histories, they had all been exposed to molds at

work and had suffered from work-related lower respiratory symptoms. The

investigations had included specific inhalation challenge (SIC) tests with

mold

extracts and serial peak expiratory flow (PEF) recordings. Using

internationally

recommended diagnostic criteria for occupational asthma (OA), we categorized

the

patients into three groups: probable, possible, and unlikely OA (156, 45, and

475 patients, respectively). The clinical details of 258 patients were

analyzed,

and their levels of microbial exposure were evaluated.

RESULTS: The agreement between the serial PEF recordings and SIC tests (both

being either positive or negative) was 56%. In the group of probable OA, mold

sensitization was found in 20%. The level of exposure and sensitization to

molds

was associated with probable OA. At 6 months, the follow-up examinations of

136

patients with probable OA showed that the symptoms were persistent, and no

improvement in spirometry was noted despite adequate treatment. Only 58% of

the

patients had returned to work.

CONCLUSIONS: Exposure to damp and moldy workplaces can induce new-onset adult

asthma. IgE mediation is a rare mechanism, whereas other mechanisms are

unknown.

http://www.ncbi.nlm.nih.gov/pubmed/20127354

[Guest guest]

yes, I did note that. a few rare things have happen to me because of my

exposure, obviously haveing green/blue cataracts that shines florissant green in

the dark and doesn't turn white until it becomes absolute cararacts in the end

must be rare.

I understand that IgE without a true allergy might be rare, that doesn't answer

why it happens, that doesn't mean that that testing I had done after my exposure

means nothing. I had specific IgE to a.f. and alternaria T. pen,N. I never made

it back for further testing.

I also understand that being highly positive with intradermal testing to many

mold mixes and the serum itself could mean I reacted to more than just mold in

that serum, and that a reactivity to mold may point to a true allergy. my whole

body was like one big cutaneous reaction and it wasn't just to mold.

I've also read that some specific molds may cause a IgE responce.

one non-allergic had cutaneous reactions. what does it mean, seventeen protiens

bound IgE, 6 being allergens. ? protiens may bind IgE but are not always

allergens?

Immunobiology. 2010 Jul 7. [Epub ahead of print]

Physico-chemical and clinico-immunologic studies on the allergenic significance

of Aspergillus tamarii, a common airborne fungus.

Vermani M, Vijayan VK, Menon B, Kausar MA, Agarwal MK.

Department of Respiratory Allergy & Applied Immunology, Vallabhbhai Patel Chest

Institute, University of Delhi, Delhi 110007, India.

Abstract

Aspergillus-derived inhalant allergens play an important role in the etiology of

allergic respiratory diseases. In the present study, we investigated the

allergenic potential of Aspergillus tamarii, quantified its airborne content,

identified its major/minor allergens, evaluated heterogeneity of patients' IgE

response to its allergens and cross-reactivity of its allergens with other

Aspergillus allergens. Skin prick tests with A tamarii extract were performed on

300 patients of bronchial asthma/allergic rhinitis and 20 healthy volunteers.

Sixty-six patients (22%) elicited positive cutaneous reactions to A tamarii

extract. Only one of the 20 non-allergic healthy volunteer showed a mild

positive cutaneous reaction. Allergen-specific IgE levels increased with

increase in patients' cutaneous response (0% in negative to 100% in 3+/4+). The

skin positivity and allergen-specific IgE levels were significantly higher in

patients compared to healthy volunteers (P>0.05). However, no differences were

found for these two parameters among patients of bronchial asthma, allergic

rhinitis and bronchial asthma with allergic rhinitis. The airborne A tamarii

allergen content was highest in February and October. A tamarii extract revealed

at least 22 proteins (13.3-120kDa). Seventeen of these proteins bound patients'

IgE with six being major allergens (13.3, 23, 25, 34, 39.5, 43kDa). Three major

allergens (13.3, 34, 43kDa) were found to cross-react with A flavus and one

(34kDa) with A niger. Our results revealed that A tamarii allergen(s) are

present in the air, which might serve as important inhalant allergens in

IgE-mediated allergic respiratory diseases.

PMID: 20667623 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/20667623

--- In , " Jack Thrasher, Ph.D. " <toxicologist1@...>

wrote:

[Guest guest]

correction> and that a reactivity to mold may NOT point to a true allergy.

--- In , " osisposis " <jeaninem660@...>