Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome.

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Severity of symptom flare after moderate

exercise is linked to cytokine activity in chronic fatigue

syndrome.

White AT, Light AR, Hughen RW, Bateman L, s TB,

Hill HR, Light KC.

Psychophysiology. 2010 Mar 4. [Epub ahead of

print]

Department of Exercise and Sport Science,

University of Utah, Salt Lake City, Utah, USA.

Abstract

Chronic fatigue syndrome (CFS) patients often report

symptom flare (SF) for >24 h after moderate exercise (post-ex). We

hypothesized that SF is linked to increases in circulating cytokines and CD40

Ligand (CD40L). In 19 CFS patients and 17 controls, mental and physical fatigue

and pain symptom ratings were obtained together with serum for 11 cytokines and

CD40L before and at 0.5, 8, 24, and 48 h post-ex. Before exercise, CFS had lower

CD40L (p<.05) but similar cytokines versus controls. In subgroups based on SF

at 48 h, high SF patients (n=11) increased in IL-1beta, IL-12, IL-6, IL-8,

IL-10, and IL-13 (p<.05) 8 h post-ex. Low SF patients (n=8) showed post-ex

decreases in IL-10, IL-13, and CD40L, and controls decreased in IL-10, CD40L,

and TNFalpha (p<.05). Thus, in CFS, cytokine activity may vary directly with

SF, which may explain prior inconsistent findings.

 

PMID: 20230500 [PubMed - as supplied by

publisher]