Re: Severity of symptom flare after moderate exercise is link...

March 20, 2010

Yikes! I am healthy most of the time, but I do get this one. Swelling

and extreme fatigue after moderate exercise. I used to swim a mile a day

most days and do spinning classes three times a week. No mas. Does the

article say how to stop this?

In a message dated 3/20/2010 9:03:05 A.M. Pacific Daylight Time,

kmtown2003@... writes:

Severity of symptom flare after moderate

exercise is linked to cytokine activity in chronic fatigue

syndrome.

White AT, Light AR, Hughen RW, Bateman L, s TB,

Hill HR, Light KC.

Psychophysiology. 2010 Mar 4. [Epub ahead of

print]

Department of Exercise and Sport Science,

University of Utah, Salt Lake City, Utah, USA.

Abstract

Chronic fatigue syndrome (CFS) patients often report

symptom flare (SF) for >24 h after moderate exercise (post-ex). We

hypothesized that SF is linked to increases in circulating cytokines and

CD40

Ligand (CD40L). In 19 CFS patients and 17 controls, mental and physical

fatigue

and pain symptom ratings were obtained together with serum for 11

cytokines and

CD40L before and at 0.5, 8, 24, and 48 h post-ex. Before exercise, CFS had

lower

CD40L (p<.05) but similar cytokines versus controls. In subgroups based on

SF

at 48 h, high SF patients (n=11) increased in IL-1beta, IL-12, IL-6, IL-8,

IL-10, and IL-13 (p<.05) 8 h post-ex. Low SF patients (n=8) showed post-ex

decreases in IL-10, IL-13, and CD40L, and controls decreased in IL-10,

CD40L,

and TNFalpha (p<.05). Thus, in CFS, cytokine activity may vary directly

with

SF, which may explain prior inconsistent findings.

PMID: 20230500 [PubMed - as supplied by

publisher]

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