Allergic Symptoms in Children with Autism Spectrum Disorders. More than Meets

[Guest guest]

http://www.ncbi.nlm.nih.gov/pubmed/21210299

J Autism Dev Disord. 2011 Jan 6. [Epub ahead of print]

Brief Report: " Allergic Symptoms " in Children with Autism Spectrum Disorders.

More than Meets the Eye?

Angelidou A, Alysandratos KD, Asadi S, Zhang B, Francis K, Vasiadi M,

Kalogeromitros D, Theoharides TC.

Molecular Immunopharmacology and Drug Discovery Laboratory, Department of

Molecular Physiology and Pharmacology, Tufts University School of Medicine,

Suite M & V-208, 136 on Avenue, Boston, MA, 02111, USA.

Abstract

Many children with Autism Spectrum Disorders (ASD) have either family and/or

personal history of " allergic symptomatology " , often in the absence of positive

skin or RAST tests. These symptoms may suggest mast cell activation by

non-allergic triggers. Moreover, children with mastocytosis or mast cell

activation syndrome (MCAS), a spectrum of rare diseases characterized by

increased number of activated mast cells in many organs, appear to have ASD at a

rate tenfold higher (1/10 children) than that of the general population (1/100

children). Mast cell activation by allergic, infectious, environmental and

stress-related triggers, especially perinatally, would release pro-inflammatory

and neurotoxic molecules. We speculate these could disrupt the gut-blood-brain

barriers, thus contributing to brain inflammation and ASD pathogenesis.

Increased mast cell responsiveness may define at least a subgroup of ASD

subjects, who could benefit from inhibition of mast cell activation

[Guest guest]

I've been researching Mast Cells quite a bit lately. Especially, because my

saga began after nasal inhalation injury and the nasal mucosa has a lot of mast

cells already.

Anyone taking cromolyn as a mast cell stabilizer? I just started but it's

suppposed to take a couple weeks.

My take on it is that if these overactive mast cells leak out their

proinflammatory guts, it could be stimulating my afferent trigeminal and vagal

nerves leading to the odd neuralgias and brain fog that I have.. Just a

thought.. one of the many.

Thanks,

Tom

Many children with Autism Spectrum Disorders (ASD) have either family and/or

personal history of " allergic symptomatology " , often in the absence of positive

skin or RAST tests. These symptoms may suggest mast cell activation by

non-allergic triggers. Moreover, children with mastocytosis or mast cell

activation syndrome (MCAS), a spectrum of rare diseases characterized by

increased number of activated mast cells in many organs, appear to have ASD at a

rate tenfold higher (1/10 children) than that of the general population (1/100

children). Mast cell activation by allergic, infectious, environmental and

stress-related triggers, especially perinatally, would release pro-inflammatory

and neurotoxic molecules. We speculate these could disrupt the gut-blood-brain

barriers, thus contributing to brain inflammation and ASD pathogenesis.

Increased mast cell responsiveness may define at least a subgroup of ASD

subjects, who could benefit from inhibition of mast cell activation

>

[Guest guest]

I think over active mast cell responces can cause some symptoms and can be a

factor exspecially with re-exposure to some or maybe most molds. I think this

could be either or allergic or non-allergic.

I read that it is a factor with AF exposure.

whats interesting is that when I tried Cromolyn,with a neubulizer, I had a

intolerance reaction to it in my lungs, it even made the good effects of the

albuteral done right before it disappear, pretty obvious reaction.

but albuteral sulfate helps with the reactive airway restriction which is a big

factor for me with re-exposures to manily chemicals,voc's,mold voc's and to some

lower level also a condition just there to some level based on the damage that

has accured to my lungs,airways. also these reactions of caughing and airways

closeing up are listed as RADS symptoms from chemical exposures.

seems what exactly was going on with possable different reactions would depend

on TH1,TH2,TH17 and what is causeing the reaction.

dont forget macrophages on the dark side and the danger signal.

and regarless of weither it's toxic, irritant or allergic we have a inflammatory

reaction somewhere to some level .

and yep, I cant keep it straight in my head unless I'm researching and

consentrateing on that subject. and seriously I dont want to even try to soak

that part in anymore, it's to complacated and you cant sort out what may or

maynot be affecting you when it comes to mold re-exposures, could be proteins,

irritants, toxins, and what the body reconizes as danger or not deturmines what

set of cells react,ect.

all the answers just are not there.

I do know that mast cells are in one of the first called on cell reaction when

it comes to exposures, and chronic mast cell responce can cause some damage.

like TH17, they can be helpful or harmful.

the only advice I can give you is to read macrophages on the dark side and

danger signals.

and I'm sure if I got any of this grossly stated wrong someone well correct me.

I just cant get deep into this subject right now, to many other things on my

mind I have to deal with.

do read those articles if you haven't, if I get a minute I well look in archive

for a post with those and a few on mast cells and fungal or mold effects.

>

> I've been researching Mast Cells quite a bit lately. Especially, because my

saga began after nasal inhalation injury and the nasal mucosa has a lot of mast

cells already.

>

> Anyone taking cromolyn as a mast cell stabilizer? I just started but it's

suppposed to take a couple weeks.

>

> My take on it is that if these overactive mast cells leak out their

proinflammatory guts, it could be stimulating my afferent trigeminal and vagal

nerves leading to the odd neuralgias and brain fog that I have.. Just a

thought.. one of the many.

>

> Thanks,

> Tom

>