Re: PURIFICATION AND COMPARATIVE NEUROTOXICITY OF THE TRI...

[Guest guest]

Jeannie to me you are the queen of information

Janet

In a message dated 3/13/2011 8:58:17 P.M. Eastern Daylight Time,

jeaninem660@... writes:

ugg, makes my head hurt just thinking about it. I know, it should be done.

it's something I planned on doing, just never did, mainly because my

organization skills are still lacking and still to many other distractions to

deal with. should have started it along time ago. things that are overwelling

to me cause me to just go brain dead,

I actually looked into this before and just the thought of trying to

organize stopped me in my tracks.

this never was a problem for me before WDB exposure.

> >

> > Jeanine,

> >

> > You really should start a website where all your research of finding

these

> > great papers are stored. Maybe you could find someone to start one for

> > you...and give you credit for all your hours of research. You could

call it

> > " The Truth About Truth About Mold "

> >

> >

> > In a message dated 3/13/2011 4:07:43 P.M. Pacific Daylight Time,

> > jeaninem660@ writes:

> >

> > PURIFICATION AND COMPARATIVE NEUROTOXICITY OF THE TRICHOTHECENES

> > SATRATOXIN G AND RORIDIN L2 FROM STACHYBOTRYS CHARTARUM

> >

> > __http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808125/?tool=pubmed__'>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808125/?tool=pubmed__

(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808125/?tool=pubmed_)

> > (_http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808125/?tool=pubmed_

(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808125/?tool=pubmed) )

> >

> > 2010 Aug;116(2):433-40. Epub 2010 May 13.

> >

> > Kinetics of satratoxin g tissue distribution and excretion following

> > intranasal exposure in the mouse.

> >

>

[Guest guest]

Thank you Janet, I'm not doing much anymore, just sometimes to see if I can find

anything new. I think theres probably more recend articles out there I just

haven't had the time to search for them.

not long ago I posted a study on mVOC'S and neurological effects, I cant find it

now, it would go along well with the EPA study, if anyone remembers it or tagged

it can they please repost it.

I know I saved it but cant locate it now, thanks.

>

> Jeannie to me you are the queen of information

> Janet

>

[Guest guest]

I could not find your previously posted study, but there is an excellent 124

page study, online, called " The Mechanisms of Neurotoxicity induced by a

stachybotrys chartarum trichothecene mycotoxin in an 'in vitro' model. "

Unfortunately, I found it impossible to copy the link to this PhD thesis paper.

If you Google the name of the author, " Enusha Karunasena " , the above mentioned

paper is the very first item that will appear in your search results. What makes

his paper valuable, is that the author is studying " HUMAN " cell reactions [in

test tubes], and not the usual mouse [murine] subjects, as in most scientific

papers.

God Bless, Joe

.................

> >

> > Jeannie to me you are the queen of information

> > Janet

> >

>

[Guest guest]

Thanks Joe, well check it out. was mistaken, heres the one I had posted, below,

voc's and neurotoxicity,

124 page study, online, called " The Mechanisms of Neurotoxicity induced by a

stachybotrys chartarum trichothecene mycotoxin in an 'in vitro' model. " Google

the name of the author, " Enusha Karunasena " ,

Neurotoxicity of Fungal Volatile Organic Compounds

Neurotoxicity of Fungal Volatile Organic Compounds in Drosophila melanogaster

Arati A. Inamdar1, Prakash Masurekar and Joan Wennstrom

+ Author Affiliations

Department of Plant Biology and Pathology, Rutgers, The State University of New

Jersey, New Brunswick, New Jersey 08901

1To whom correspondence should be addressed at 59, Dudley Road, Foran Hall, Room

291D, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901. Fax:

(732) 932-9441. E-mail: inamdar@....

Received February 18, 2010.

Accepted July 6, 2010.

Abstract

Many volatile organic compounds (VOCs) are found in indoor environment as

products of microbial metabolism. In damp indoor environments, fungi are

associated with poor air quality. Some epidemiological studies have suggested

that microbial VOCs have a negative impact on human health. Our study was

designed to provide a reductionist approach toward studying fungal VOC–mediated

toxicity using the inexpensive model organism, Drosophila melanogaster, and pure

chemical standards of several important fungal VOCs. Low concentrations of the

following known fungal VOCs, 0.1% of 1-octen-3-ol and 0.5% of 2-octanone; 2,5

dimethylfuran; 3-octanol; and trans-2-octenal, caused locomotory defects and

changes in green fluorescent protein (GFP)- and antigen-labeled dopaminergic

neurons in adult D. melanogaster. Locomotory defects could be partially rescued

with L-DOPA. Ingestion of the antioxidant, vitamin E, improved the survival span

and delayed the VOC-mediated changes in dopaminergic neurons, indicating that

the VOC-mediated toxicity was due, in part, to generation of reactive oxygen

species.

Key words

dopamineDrosophila melanogasterfungiParkinson's diseasesick building

syndromevolatile organic compounds

http://toxsci.oxfordjournals.org/content/117/2/418.abstract