Re: Building-associated neurological damage modeled in human cells: a mechanism of neurotoxic effects by exposure to mycotoxins in the indoor environment.

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http://achemmic.com/files/Building_Associated_Neurological_Damage_Modeled_in_Hum\

an_Cells_A_Mechanism_of_Neurotoxic_Effects_by_Exposure_to_Mycotoxins_in_the_Indo\

or_Environment_2010.pdf

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> Building-associated neurological damage modeled in human cells: a

> mechanism of neurotoxic effects by exposure to mycotoxins in the indoor

> environment.

>

> Karunasena E, Larrañaga MD, Simoni JS, DR, Straus DC.

> Mycopathologia. 2010 Dec;170(6):377-90. Epub 2010 Jun 13.

>

> Department

> of Animal & Food Sciences, Texas Tech University, Lubbock, TX 79409, USA.

enusha.karunasena@...

>

> Abstract

>

> Damage to human neurological system cells resulting from exposure to

> mycotoxins confirms a previously controversial public health threat for

> occupants of water-damaged buildings. Leading scientific organizations

disagree

> about the ability of inhaled mycotoxins in the indoor environment to cause

> adverse human health effects. Damage to the neurological system can result

from

> exposure to trichothecene mycotoxins in the indoor environment. This study

> demonstrates that neurological system cell damage can occur from satratoxin H

> exposure to neurological cells at exposure levels that can be found in

> water-damaged buildings contaminated with fungal growth. The constant

activation

> of inflammatory and apoptotic pathways at low levels of exposure in human

brain

> capillary endothelial cells, astrocytes, and neural progenitor cells may

amplify

> devastation to neurological tissues and lead to neurological system cell

damage

> from indirect events triggered by the presence of trichothecenes.

>

> PMID: 20549560 [PubMed - in process]

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