Parasites,immune system changes as infection procedes

[Guest guest]

this is about parasites,but interesting about how the immune system can change

as the infection progresses.I read something on fungal infections that alsO

pointed to immune system changes after 4 or5 days.

I think I got it turned around on the mature and immature dc's.

but they play a role in activating MHC, so I just think maybe there is a point

where the immune system can be supressed somehow and MHC may not be a factor

than. so it seems that if this is a possability, than if you dont think theres

fungal infections or even bacterial infections going on with WDB exposures,

maybe you wouldn't believe that the immune system can become suppressed.? I

dont know, I'm just wondering if you can have a supressed immune system and

possabily still have antigen presentation going on. I also fell that along with

getting damaged tissues,infection becomes a more likely problem.

than theres compliment,which I've read before, with fungal infection also may

also change antigen presentation abilities.

so I just dont know, but the possability is there.

so this is kindof where I stand. I cant really be factual because it's been to

long sence I had my brain tottally rapped around this and even than I had these

questions. theres just to much to the immune system and alot of spectulation and

not many clear cut answers.

to top it off theres a somewhat different immune function to different sets of

organs, the second brain and so on.

the danger signal model made alot of things make more sence to me, but again, I

haven't been in that kind of research mode for quite awhile as I have something

else on my plate. but I just fell theres a good possability that if we have

immune supression, it's not going to mater what bad genes we have.

ps,you can get the full text by clicking on the pp number and than clicking on

the pdf or html at the top of the page.through the second link

http://www3.interscience.wiley.com/cgi-bin/fulltext/123345131/HTMLSTART

http://www3.interscience.wiley.com/journal/123490544/abstract?CRETRY=1 & SRETRY=0

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this was interesting

on TH17

http://www3.interscience.wiley.com/cgi-bin/fulltext/121489807/HTMLSTART

Studies on the role of IL-17-producing T cells in immunity to fungal infections

have generated more conflicting findings. Clearance of the fungal pathogen

Crypotococcus neoformans is delayed and survival reduced in IL-23p19-/- mice

[92]. Similarly, IL-17AR-/- mice have decreased resistance to systemic challenge

with C. albicans; higher fungal burden in the kidney and reduced survival in

knockout mice were associated with reduced mobilization of peripheral

neutrophils and their recruitment to the kidney [93]. However, there is also

evidence that IL-23 and IL-17 may have a negative role in immunity to fungal

infection. IL-23p19-/- mice were less susceptible to intragastric infection with

C. albicans and intranasal infection with Aspergillus fumigatus and this was

associated with enhanced IL-12 and IFN- production [94]. This study concluded

that IL-23 and IL-17 impaired the anti-fungal immunity by suppressing Th1

responses and the fungicidal activity of neutrophils.