Re: Benefit of COQ10 and exercise

[Guest guest]

Sorry about the late reply, but this study isn't so positive about co

Q10.

http://www.ncbi.nlm.nih.gov/pubmed/12014827

How to re-energise old mitochondria without shooting yourself in the

foot.

Driver C, Georgiou A.

National Ageing Research Institute, Parkville, Australia.

c.driver@...

In old humans and pathologies associated with mitochondrial

mutations, deletions in mitochondrial DNA have been associated with

failing function. Investigations have been reported where treatment

with a number of micronutrients, such as coenzyme Q10, have been used

to re-energise failing tissues. Bioenergy changes in ageing

Drosophila have been observed which indicate similar changes in

mitochondrial function in old age. Reserves of carbohydrate and fat

fall and food intake rises. Biochemical changes include falling

mitochondrial enzymes. Mitochondrial DNA contains increased amounts

of sequences corresponding to deletions. Both coenzyme Q10 and

nicotinamide in large doses successfully reversed bioenergy changes

in aged Drosophila. However, only nicotinamide was able to reduce

short term mortality and increase life span, whereas coenzyme Q10

increased mortality and reduced life span. Production of reactive

oxygen species (ROS) was increased in coenzyme Q10 treated flies,

whereas nicotinamide reduced ROS production. It is suggested that ROS

production may account for these longevity differences. Large doses

of two micronutrients have been successful in reversing the age-

associated bioenergy deficit in Drosophila. This response is similar

to clinical reports of re-energising tissues where mitochondrial

damage has been observed. However, this work highlights a danger for

some micronutrients, such as coenzyme Q10, that clinical efficacy may

be limited by increased ROS production.

===========================

Regards,

Johan Bastiaansen

Hasselt, Belgium

>

> Effects of acute and 14-day coenzyme Q10 supplementation on exercise

> performance in both trained and untrained individuals

>

> Cooke email, Mike Iosia email, Buford email,

> Shelmadine email, Geoffrey Hudson email, Chad Kerksick email,

> Rasmussen email, Mike Greenwood email, Leutholtz

> email, Darryn Willoughby email and Kreider email

>

> Journal of the International Society of Sports Nutrition 2008,

> 5:8doi:10.1186/1550-2783-5-8

> Published: 4 March 2008

> Abstract (provisional)

>

> Background

>

> To determine whether acute (single dose) and/or chronic (14-days)

> supplementation of CoQ10 will improve anaerobic and/or aerobic

> exercise performance by increasing plasma and muscle CoQ10

> concentrations within trained and untrained individuals.

> Methods

>

> Twenty-two aerobically trained and nineteen untrained male and

female

> subjects (26.1+/-7.6 yrs, 172+/-8.7 cm, 73.5+/-17 kg, and 21.2+/-

7.0%)

> were randomized to ingest in a double-blind manner either 100 mg of

a

> dextrose placebo (CON) or a fast-melt CoQ10 supplement (CoQ10)

twice a

> day for 14-days. On the first day of supplementation, subjects

donated

> fasting blood samples and a muscle biopsy. Subjects were then given

> 200 mg of the placebo or the CoQ10 supplement. Sixty minutes

following

> supplement ingestion, subjects completed an isokinetic knee

extension

> endurance test, a 30-second wingate anaerobic capacity test, and a

> maximal cardiopulmonary graded exercise test interspersed with

> 30-minutes of recovery. Additional blood samples were taken

> immediately following each exercise test and a second muscle biopsy

> sample was taken following the final exercise test. Subjects

consumed

> twice daily (morning and night), 100mg of either supplement for a

> period of 14-days, and then returned to the lab to complete the same

> battery of tests. Data was analyzed using repeated measures ANOVA

with

> an alpha of 0.05.

> Results

>

> Plasma CoQ10 levels were significantly increased following 2 weeks

of

> CoQ10 supplementation (p<0.001); while a trend for higher muscle

CoQ10

> levels was observed after acute CoQ10 ingestion (p=0.098). A trend

for

> lower serum superoxide dismutase (SOD) was observed following acute

> supplementation with CoQ10 (p=0.06), whereas serum malondialdehyde

> (MDA) tended to be significantly higher (p<0.05). Following acute

> ingestion of CoQ10, plasma CoQ10 levels were significantly

correlated

> to muscle CoQ10 levels; maximal oxygen consumption; and treadmill

time

> to exhaustion. A trend for increased time to exhaustion was observed

> following 2 weeks of CoQ10 supplementation (p=0.06).

> Conclusions

>

> Acute supplementation with CoQ10 resulted in higher muscle CoQ10

> concentration, lower serum SOD oxidative stress, and higher MDA

levels

> during and following exercise. Chronic CoQ10 supplementation

increased

> plasma CoQ10 concentrations and tended to increase time to

exhaustion.

> Results indicate that acute and chronic supplementation of CoQ10 may

> affect acute and/or chronic responses to various types of exercise.

>

> W.G.

> Ubermensch Sports Consultancy

> San Diego,CA

>