Re: Re: aciclovir/ibuprofen

[Guest guest]

Hi all,Just found an interesting piece of information on Ibuprofen's dual effect; reducing inflammation and working as an antifungal (see below). I thought this might be of interest to others as well. I had never heard, that Ibuprofen could combat yeast, but it apparently can! We haven't used Ibuprofen, but now I'm considering it, as my son's on antifungals and antivirals since Nov/Dec (fluconazol and Zovirax) and I feel like the yeast is still not under control. He's made some gains while on Zovirax (especially gross motor), but teeth grinding has come back as well as some silly behaviour, so I think I need to find more ways to address the yeast. He's taking probiotics and enzymes (not the ones with cellulase, though, as this might interfere with his liquid Zovirax, I think), and I'm planning

on starting a garlic supplement. If anyone can recommend other ways to address the yeast, that would be great. Naturally we're doing what we can with the diet, eventhough daycare is not as cooperative as I wished...Take care, NinaQuote from: http://www.yeast-candida-infections-uk.co.uk/treatment-of-autism-and-yeast-infections"Taking Ibuprofen has a duel effect ..reducing inflammation & works as an Antifungal..It’s not a substitute for Olmesartan, but useful

none-the-less Antifungal activity of ibuprofen alone and in combination with fluconazole against Candida species.

Pina-Vaz C, Sansonetty F, Rodrigues AG, ez-De-Oliveira J, Fonseca AF, Mardh PA.

Department of Microbiology, Porto School of Medicine, University of Porto, Portugal. micfam@...

Ibuprofen, a non-steroidal anti-inflammatory drug, exhibited antimicrobial activity against Candida albicans and non-albicans strains. At 10 mg/ml, ibuprofen showed a rapid cidal activity against exponential growth phase C. albicans, accompanied by rapid and extensive

leakage of intracellular K+, permeation to propidium iodide, lysis of spheroplasts and severe membrane ultrastructural alterations. These results indicate that the killing of Candida cells is due to direct damage to the cytoplasmic membrane. At 5 mg/ml, ibuprofen inhibited growth; however, it did not kill the yeasts and did not directly affect the cytoplasmic membrane. Evaluation of yeast metabolic vitality with the fluorescent probe FUN-1 showed that growth inhibition induced by the

fungistatic drug concentration was due to metabolic alterations. The combination of ibuprofen with fluconazole resulted in synergic activity with eight of the 12 Candida strains studied, including four of the five

fluconazole-resistant strains. The MICs of fluconazole for the fluconazole-resistant strains decreased 2-128-fold when the drug was associated with ibuprofen. When in combination with fluconazole, MICs for ibuprofen decreased by up to 64-fold for all the 12 strains studied.

These results point to the practicability of using ibuprofen, alone or in combination with azoles, in the treatment of candidosis, particularly

when applied topically, taking advantage of the drug's antifungal and anti-inflammatory properties.

PMID: 10966233 see also PMID: 15679664 , PMID: 10952582 , PMID: 11128557 sodium salicylate" To: Autism-Biomedical-Europe Sent: Thursday, January 19, 2012 1:09 AM Subject: Re: aciclovir/ibuprofen

Kim, there is a yahoo list. Primarily US people. Pretty good, interesting. 's son has a condition called hypergammaglobulinanaemia, (phew) which is in 's side of our family. Jay has it but it came out in another gene, expressed differently, and we chased it with Great Ormond St, along with Pandas. Long story but if you've got autism it can't be treated like everything else. Hence that name because the kids often get denied treatment. Be worth you reading the Myth of Autism if you haven't already Didn't use ibuprofen because of , but interesting he found it useful. Used it because it seemed the obvious thing to lower inflammation and help immune system by doing this xxxxx Eileen

> > > >

> > > >

> > > > Hi za,

> > > > Hope Natasa is watching as well.

> > > >

> > > > The first time we did Valtrex, we saw side effects in the first week on

> day

> > 5. Side effects for us were: head-pressing against us and hard surfaces (like

> > head banging, to relieve inflammation) and stupidly massive yeast. Lots of

> > stimming, lining up, to cope with extra stress on the body. This time, with

> > acyclovir, we haven't had any. All we've seen is great gains. We have

> learned

> > to a certain extent from the first time.

> > > >

> > > > You might not get any side effects at all but most of us do.

> > > >

> > > > In a nutshell, to avoid the side-effects, i.e. to keep the extra stress on

> > the body in control which might result from anti-viral use, you need to:

> > > >

> > > > Increase your yeast protocol, after observation of first week.

> > > > We upped probiotics at night. We use CP1 and Candex as it doesn't contain

> > Streptococcus Thermophilis which for some reason has negative impact on PANDAS

> > kids. We haven't used as much Candex as we used to, but are working it back

> in

> > again (remember we totally came off biomed for a while because we hadn't had a

> > break for six years).

> > > >

> > > > You need to manage inflammation - consider Ibuprofen. Not good for kids

> > with gut issues, granted, but you are looking at bigger picture and not long

> > term use. We did Valtrex a few years ago which is six times more bioavailable

> > than Acyclovir. We had massive stimming (we needed prescription yeast killers

> > and at that point had to fight for them because this was all new) and pressing

> > head against surfaces to relieve pain. This time on Acyclovir, we did a week

> of

> > regular ibuprofen at the beginning of the protocol. Then occasional doses if

> > needed on the odd rough day. This worked for us. We didn't get the head

> > pressing and all the stims. If we had a really bad moment we'd put it in

> again,

> > but not regularly. Also you could up the fish oils. That helps as well. You

> > could also up fish oil protocol, that has helped here.

> > > >

> > > > Manage the strep. Another thing is we have got J on Zithro at the same

> time

> > as the anti-viral. This won't make it necessarily what DG will prescribe for

> > Eddie because we had massive strep titres. It depends. But Zithro has an

> > overall anti-inflammatory effect on the body. So this begs question, did J

> avoid

> > side-effects this time because of Zithro or Ibuprofen, because he was on both?

> > I think Ibuprofen helps because when he was on Zithro alone for strep, he

> still

> > had inflammation so we needed something extra, particularly at the start. It

> is

> > not something I want long term, but it is helping right now, along with the

> rest

> > of the world I'm looking for more healthy ways.

> > > >

> > > > Getting the strep/tics under control before you start antivirals seems to

> > have helped this time. We didn't know strep was rampant the first time we did

> > Valtrex.

> > > >

> > > > To me, if you have viral and strep at same time, you are going to battle

> > inflammation and if you can do that you are on a winner. Its so much better

> for

> > us this time. Whatever you do, don't suddenly stop the anti-virals but I

> guess

> > has told you that.

> > > >

> > > > Liver and Kidney Support. Essential to clear systemic prescription drugs

> > through the system (and viruses). I use Liv-detox but am considering moving

> to

> > other supps.

> > > >

> > > > Methylation. You need to make sure the MB12/folinic is in place, but if

> the

> > negative effects are too much at the start, I would do that week 2/3 if not

> > established already or you won't know what's causing what.

> > > >

> > > > Managing coming off anti-virals eventually - up your strep protocol. When

> > viruses move out we have found in comes Strep.

> > > >

> > > > Isobel Ramsey gave me a tip about massaging encense oil (in a

> carrier)

> > into the feet at night, this and some music helps calm as well, so think

> > about what calms Eddie as well as supps to avoid the storm.

> > > >

> > > > If things get really awful, pick up the phone to 's sec , and

> he

> > will get back to you usually by the end of the day if its an emergency.

> > > >

> > > > Have you got some Melatonin to help with the sleep, is Eddie all right on

> > that?

> > > >

> > > > Please ask if I've been unclear and you want me to answer anything in more

> > details.

> > > >

> > > > Much love to you and Eddie

> > > > Things have got so much better in all areas here having braved this one

> out

> > for a while.

> > > >

> > > > Eil x

> > > >

> > >

> >

>