Neutrophils as a noval sorce of ECP in IgE -dependent disease

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Neutrophils as a Novel Source of Eosinophil Cationic Protein in IgE-Mediated

Processes.

These observations represent a novel view of neutrophils as possible source of

ECP in IgE-dependent diseases.

IgE can bind on neutrophils at the high-affinity receptor for IgE (FcRI) (32),

the low-affinity receptor for IgE (FcRII/CD23) (33, 34), and galectin-3 (35,

36).

Based on our experiments, we hypothesize that ECP released by neutrophils has a

biological role in IgE-induced reactions.

http://www.jimmunol.org/cgi/content/abstract/179/4/2634

Eosinophil cationic protein (ECP)

Authors' reply

http://thorax.bmj.com/content/63/2/185.2.extract

Role of ECP in Monitoring Inflammatory Conditions

http://www.medical.siemens.com/siemens/en_GLOBAL/gg_diag_FBAs/files/medical/alle\

rgy/tech_reports/zb181-b_ECP.pdf