Re: The Fusarium mycotoxins enniatins and beauvericin cause m...

[Guest guest]

why dont you write in laymens words?

In a message dated 7/26/2010 9:59:51 A.M. Eastern Daylight Time,

tigerpaw2c@... writes:

Toxicology. 2010 Jul 15. [Epub ahead of print]

The Fusarium mycotoxins enniatins and beauvericin cause mitochondrial

dysfunction by affecting the mitochondrial volume regulation, oxidative

phosphorylation and ion homeostasis.

Tonshin AA, Teplova VV, Andersson MA, Salkinoja-Salonen MS.

_http://www.ncbi.nlm.nih.gov/pubmed/20621153_

(http://www.ncbi.nlm.nih.gov/pubmed/20621153)

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State

University, Moscow RU-119899, Russia; Department of Food and Environmental

Sciences, Microbiology, University of Helsinki, Viikki Biocenter 1, POB 56,

Helsinki 00014, Finland.

Abstract

The mechanisms of cell toxicity of mycotoxins of the enniatin family

produced by Fusarium sp. enniatin B, a mixture of enniatin homologues (3% A,

20%

A(1), 19% B, 54% B1) and beauvericin, were investigated. In isolated rat

liver mitochondria, exposure to submicromolar concentrations of the enniatin

mycotoxins depleted the mitochondrial transmembrane potential, uncoupled

oxidative phosphorylation, induced mitochondrial swelling and decreased

calcium retention capacity of the mitochondria. The mitochondrial effects were

strongly connected with the potassium (K(+)) ionophoric activity of the

enniatins. The observed enniatins induced K(+) uptake by mitochondria. This

shows that the enniatins acted as ionophores highly selective for potassium

ions. The effects were observed in potassium containing media whereas less

or no effect remained to be observed when K(+) was partially or totally

replaced by isomolar concentrations of Na(+). The rank order of enniatin

induced mitochondrial impairment was

[Guest guest]

These tests were performed on mitochondria isolated from cells and tests were

then performed in test tubes. Mitochondria are the cellular organelles that

utilized oxygen we breathe and then converts the use of the oxygen into energy

producing chemicals called adenosine triphosphate (ATP). ATP is the energy

source to metabolize organic compounds we consume as food and cert them into

proteins, DNA, RNA and by-products excreted in the urine, feces and bile.

Abscence of the function of mitochondria leads to chronic fatigue and eventually

death.

The only problem with this study is that it was done in a test tube on isolated

mitochondria. We do not know for sure what occurs in the living cell. A study

such as this sets up future studies on whole living cells.

You can ago to Wikipedia and read on mitochondria.

Jack-Dwayne: Thrasher, Ph.D.

Toxicologist/Immunotoxicologist/Fetaltoxicologist

www.drthrasher.org

toxicologist1@...

Off: 916-745-4703

Cell: 575-937-1150

L. Crawley, M.ED., LADC

Trauma Specialist

sandracrawley@...

916-745-4703 - Off

775-309-3994 - Cell

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[Guest guest]

Dr Thrasher,

Are the species and resultant toxins tested in this study generated in damp

buildings or food? Fusarium is more often associated with moldy food.

However, it raises the question do other toxins from WDB have a similar effect

on mitochondria?

Carl Grimes

Healthy Habitats LLC

(fm my Blackberry)

Re: [] The Fusarium mycotoxins enniatins and beauvericin

cause m...

These tests were performed on mitochondria isolated from cells and tests were

then performed in test tubes. Mitochondria are the cellular organelles that

utilized oxygen we breathe and then converts the use of the oxygen into energy

producing chemicals called adenosine triphosphate (ATP). ATP is the energy

source to metabolize organic compounds we consume as food and cert them into

proteins, DNA, RNA and by-products excreted in the urine, feces and bile.

Abscence of the function of mitochondria leads to chronic fatigue and eventually

death.

The only problem with this study is that it was done in a test tube on isolated

mitochondria. We do not know for sure what occurs in the living cell. A study

such as this sets up future studies on whole living cells.

You can ago to Wikipedia and read on mitochondria.

Jack-Dwayne: Thrasher, Ph.D.

Toxicologist/Immunotoxicologist/Fetaltoxicologist

www.drthrasher.org

toxicologist1@...

Off: 916-745-4703

Cell: 575-937-1150

L. Crawley, M.ED., LADC

Trauma Specialist

sandracrawley@...

916-745-4703 - Off

775-309-3994 - Cell

This message and any attachments forwarded with it is to be considered

privileged and confidential. The forwarding or redistribution of this message

(and any attachments) without my prior written consent is strictly prohibited

and may violate privacy laws. Once the intended purpose of this message has been

served, please destroy the original message contents. If you have received this

message in error, please reply immediately to advise the sender of the

miscommunication and then delete the message and any copies you have printed.

Thank you in advance for your compliance.

[Guest guest]

Carl: I am searching that question presently. I have not found a good

reference on Fusarium species in buildings. Do you have one? At present, the

mycotoxins in the study are most likely foods, e.g. grains of various types.

Jack-Dwayne: Thrasher, Ph.D.

Toxicologist/Immunotoxicologist/Fetaltoxicologist

www.drthrasher.org

toxicologist1@...

Off: 916-745-4703

Cell: 575-937-1150

L. Crawley, M.ED., LADC

Trauma Specialist

sandracrawley@...

916-745-4703 - Off

775-309-3994 - Cell

This message and any attachments forwarded with it is to be considered

privileged and confidential. The forwarding or redistribution of this message

(and any attachments) without my prior written consent is strictly prohibited

and may violate privacy laws. Once the intended purpose of this message has been

served, please destroy the original message contents. If you have received this

message in error, please reply immediately to advise the sender of the

miscommunication and then delete the message and any copies you have printed.

Thank you in advance for your compliance.

[Guest guest]

Carl: I have completed my search for Fusarium species indoors. The papers only

list genus. Therefore, what species are indoors are unknown. There are some

papers on nosocomial infections and species involved.

Jack-Dwayne: Thrasher, Ph.D.

Toxicologist/Immunotoxicologist/Fetaltoxicologist

www.drthrasher.org

toxicologist1@...

Off: 916-745-4703

Cell: 575-937-1150

L. Crawley, M.ED., LADC

Trauma Specialist

sandracrawley@...

916-745-4703 - Off

775-309-3994 - Cell

This message and any attachments forwarded with it is to be considered

privileged and confidential. The forwarding or redistribution of this message

(and any attachments) without my prior written consent is strictly prohibited

and may violate privacy laws. Once the intended purpose of this message has been

served, please destroy the original message contents. If you have received this

message in error, please reply immediately to advise the sender of the

miscommunication and then delete the message and any copies you have printed.

Thank you in advance for your compliance.