Autism, DNA and mysticism

[Guest guest]

Dr Hakon Harkonarson has looked at one gene on the 5th chromosome but if you

look at the small print it tells you nothing; as many normal people have the

same fault and

many autism children have normal genes here. Impasse but keep the dollars

rolling in. Earlier on this year it was chromosome 1; The final breakthrough.

To date, about half of the entire chromosme system has been implicated for

autism giving in effect a meaningless jumble of messages with a huge cost for

achieving just

an improvement in DNA analysis and general understanding of genes. But lots of

work for these folk.

Nothing to do with autism but thanks for the money. One day « we » may make

sense of it. They have been taking us for fools for ten years?

In fact we know pesticides, carcinogens etc can cause these deletions and

repetitions of genes so its not exactly rocket science and for all the quick

talking, it more and

more implicates an environmental insult of which brain destroying mercury still

comes out at the top of suspect lists.

For my money DNA analysis is and has been flavour of the month for years and far

too long. Even a real break through wont do much if it was to be found. Remember

elementary science says it can't be genes ALONE that cause autism.

Chemical analysis and peering down microscopes is old hat, especially when

careful researchers get film of ordinary brain cells being taken apart by some

mystical

mercurial watch maker. Too close for comfort?

The trouble with this kind of work is everyone can understand it and everyone

can pick holes in it. OK so its taking brain cells apart and leaving tangles but

it is only film

and I and my children are superbeings that can resist this! Tell it to the DNA

specialists they believe in DNA and not in thousand year old science.

But in the mystical world of DNA you just claim a breakthrough every few months

and the billions roll in. Thanks, MUGS.

No one understands you but when you show your ability at reading and

understanding simple facts these people with no one else understanding them

outside their

magic circle command all the money and when you do see through their mysticism

it screams of OOPS we have exposed little baby to something nasty in the air.

Here is breakthrough 121 on genes and autism:

The study, published in the current issue of Nature, focused on a region of DNA

that codes for two proteins called cadherin 9 and 10. These are sticky

substances

involved in a process known as neuronal cell adhesion. " They sit at the synapse,

and when the nerves come together, these molecules adhere to the nerve, "

essentially

fusing a connection in the brain, explains Dr. Hakon Harkonarson, director of

the Center for Applied Genomics at the Children's Hospital of Philadelphia

(CHOP) and a lead

author of the study. Preliminary research suggests that cadherin 10 is very

active in wiring the frontal cortex of the brain during fetal development.

A malfunction affecting one of these genes is not, in itself, enough to cause

autism, the Icelandic researcher is quick to point out. It would take a

combination of several

genetic flaws and perhaps environmental factors as well for autism to emerge.

" This gene is a key driver in causing autism in about 15% of cases, " Harkonarson

asserts.

Variations in these genes on chromosome 5 are extremely common — present in

more than half of healthy people. But they are even more common in individuals

with

autism, affecting 65%. It takes enormous genomewide association studies like

this one — what researchers call very " high powered " studies — to discern

this kind of

statistical difference. (See six tips on traveling with an autistic child.)

A second paper in Nature, published by the same team at CHOP along with

scientists at numerous other institutions, looked at a specific kind of genetic

change: deletions

and duplications of genes. While there are many such changes associated with

autism, most are very rare. This paper, however, found an intriguing pattern

among two

genes already linked to autism and nine newly identified targets. Most play a

role in two key systems in the brain. One is the same brain-wiring system —

neural cell

adhesion — implicated in the first paper. The second is a set of housekeeping

proteins — the ubiquitin system — that whisk away old brain connections and

set the

stage for new ones.

Harkonarson suggests that problems in this kind of housekeeping or maintenance

function could help explain why autistic children, who have normal-looking

brains at

birth, develop more abnormal wiring by age 2 or 3.

Note the confusion here. Most of our opponents that dont believe mercury is much

to worry about tell us that autism arrives at birth but we dont realise.

Evidently we see

as they blame us any story fits.

At birth, after birth.

This gene that gene.

Even they admit the autism is rising faster than a rocket to the moon.

I mean if its a breakthrough thats great but so far 121 breakthroughs and we are

still looking at glue in the dark while film of mercury destroying brain cells

can be seen

by anyone interested in how their child loses their brain cells.

But this isn't a break through – more a call for another scientist to be

demissioned, defrocked and thrown out on his ear.

No justice in politics, science or justice today.

Just pile up the bodies of those with « abnormal wiring » to join the

politicians, scientists and judges that deny COMMON SENSE in favour of MUMBO

JUMBO and DNA.