Biochemical and Vascular Aspects of Pediatric Chronic Fatigue Syndrome

[Guest guest]

Nothing we didn't all ready know but backs up what the good Doc's have saying

all along

 

Biochemical and Vascular Aspects of Pediatric Chronic Fatigue

Syndrome

http://archpedi.ama-assn.org/cgi/content/abstract/164/9/817

Gwen

Kennedy, PhD; Faisel Khan, PhD; Hill, PhD; Underwood, MBBS;

Jill J. F. Belch, MD Arch Pediatr Adolesc Med. 2010;164(9):817-823.

doi:10.1001/archpediatrics.2010.157

Objective  To

evaluate the biochemical and vascular aspects of pediatric chronic fatigue

syndrome/myalgic encephalomyelitis (CFS/ME).

Design  Cross-sectional clinical study.

Setting  Tayside, Scotland, United Kingdom.

Participants  Twenty-five children with CFS/ME and

23 healthy children recruited from throughout the United Kingdom.

Interventions  Participants underwent a full

clinical examination to establish a diagnosis of CFS/ME and were asked to

describe and score their CFS/ME symptoms. Biochemical markers were measured.

Arterial wave reflection was estimated to assess systemic arterial stiffness.

Main Outcome Measures  Markers of oxidative stress

and free radicals, C-reactive protein level, white blood cell apoptosis, and

arterial wave reflection.

Results  Children with

CFS/ME had increased oxidative stress compared with control individuals

(isoprostanes: 252.30 vs 215.60 pg/mL, P = .007; vitamin C, mean [sD]: 0.84

[0.26] vs 1.15 [0.28] mg/dL, P < .001; vitamin E, 8.72 [2.39] vs 10.94 [3.46]

µg/mL, P = .01) and increased white blood cell apoptosis (neutrophils: 53.7% vs

35.7%, P = .005; lymphocytes: 40.1% vs 24.6%, P = .009). Arterial stiffness

variables did not differ significantly between groups (mean augmentation index,

–0.57% vs –0.47%, P = .09); however, the derived variables significantly

correlated with total (r = 0.543, P = .02) and low-density lipoprotein (r =

0.631, P = .004) cholesterol in patients with CFS/ME but not in controls.

Conclusions  Biomedical anomalies seen in adults

with CFS/ME—increased oxidative stress and increased white blood cell

apoptosis—can also be observed in children with clinically diagnosed CFS/ME

compared with matched controls. Unlike in their adult counterparts, however,

arterial stiffness remained within the reference range in these pediatric

patients.

Author Affiliations: Vascular and

Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research,

Centre for Cardiovascular and Lung Biology, Division of Medical Sciences,

Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom.



[Guest guest]

Thanks K. good find.

Biochemical and Vascular Aspects of Pediatric Chronic Fatigue Syndrome

http://archpedi.ama-assn.org/cgi/content/abstract/164/9/817

[Guest guest]

a: Is there anyway you can locate Dr. Kennedy's email/ I have tried

with no luck

[] Biochemical and Vascular Aspects of Pediatric Chronic

Fatigue Syndrome

Nothing we didn't all ready know but backs up what the good Doc's have saying

all along

Biochemical and Vascular Aspects of Pediatric Chronic Fatigue

Syndrome

http://archpedi.ama-assn.org/cgi/content/abstract/164/9/817

Gwen

Kennedy, PhD; Faisel Khan, PhD; Hill, PhD; Underwood,

MBBS;

Jill J. F. Belch, MD Arch Pediatr Adolesc Med. 2010;164(9):817-823.

doi:10.1001/archpediatrics.2010.157

Objective To

evaluate the biochemical and vascular aspects of pediatric chronic fatigue

syndrome/myalgic encephalomyelitis (CFS/ME).

Design Cross-sectional clinical study.

Setting Tayside, Scotland, United Kingdom.

Participants Twenty-five children with CFS/ME and

23 healthy children recruited from throughout the United Kingdom.

Interventions Participants underwent a full

clinical examination to establish a diagnosis of CFS/ME and were asked to

describe and score their CFS/ME symptoms. Biochemical markers were measured.

Arterial wave reflection was estimated to assess systemic arterial stiffness.

Main Outcome Measures Markers of oxidative stress

and free radicals, C-reactive protein level, white blood cell apoptosis, and

arterial wave reflection.

Results Children with

CFS/ME had increased oxidative stress compared with control individuals

(isoprostanes: 252.30 vs 215.60 pg/mL, P = .007; vitamin C, mean [sD]: 0.84

[0.26] vs 1.15 [0.28] mg/dL, P < .001; vitamin E, 8.72 [2.39] vs 10.94 [3.46]

µg/mL, P = .01) and increased white blood cell apoptosis (neutrophils: 53.7%

vs

35.7%, P = .005; lymphocytes: 40.1% vs 24.6%, P = .009). Arterial stiffness

variables did not differ significantly between groups (mean augmentation

index,

–0.57% vs –0.47%, P = .09); however, the derived variables significantly

correlated with total (r = 0.543, P = .02) and low-density lipoprotein (r =

0.631, P = .004) cholesterol in patients with CFS/ME but not in controls.

Conclusions Biomedical anomalies seen in adults

with CFS/ME—increased oxidative stress and increased white blood cell

apoptosis—can also be observed in children with clinically diagnosed CFS/ME

compared with matched controls. Unlike in their adult counterparts, however,

arterial stiffness remained within the reference range in these pediatric

patients.

Author Affiliations: Vascular and

Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research,

Centre for Cardiovascular and Lung Biology, Division of Medical Sciences,

Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom.