The Fusarium mycotoxins enniatins and beauvericin cause mitochondrial dysfunctio

[Guest guest]

Toxicology. 2010 Jul 15. [Epub ahead of print]

The Fusarium mycotoxins enniatins and beauvericin cause mitochondrial

dysfunction by affecting the mitochondrial volume regulation, oxidative

phosphorylation and ion homeostasis.

Tonshin AA, Teplova VV, Andersson MA, Salkinoja-Salonen MS.

http://www.ncbi.nlm.nih.gov/pubmed/20621153

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State

University, Moscow RU-119899, Russia; Department of Food and Environmental

Sciences, Microbiology, University of Helsinki, Viikki Biocenter 1, POB 56,

Helsinki 00014, Finland.

Abstract

The mechanisms of cell toxicity of mycotoxins of the enniatin family produced by

Fusarium sp. enniatin B, a mixture of enniatin homologues (3% A, 20% A(1), 19%

B, 54% B1) and beauvericin, were investigated. In isolated rat liver

mitochondria, exposure to submicromolar concentrations of the enniatin

mycotoxins depleted the mitochondrial transmembrane potential, uncoupled

oxidative phosphorylation, induced mitochondrial swelling and decreased calcium

retention capacity of the mitochondria. The mitochondrial effects were strongly

connected with the potassium (K(+)) ionophoric activity of the enniatins. The

observed enniatins induced K(+) uptake by mitochondria. This shows that the

enniatins acted as ionophores highly selective for potassium ions. The effects

were observed in potassium containing media whereas less or no effect remained

to be observed when K(+) was partially or totally replaced by isomolar

concentrations of Na(+). The rank order of enniatin induced mitochondrial

impairment was

[Guest guest]

Does this mean that it depleats your body of potassium (Vit K) ??

 

God Bless !!

dragonflymcs

Mayleen

________________________________

From: KC <tigerpaw2c@...>

Sent: Mon, July 26, 2010 9:51:40 AM

Subject: [] The Fusarium mycotoxins enniatins and beauvericin cause

mitochondrial dysfunctio

 

Toxicology. 2010 Jul 15. [Epub ahead of print]

The Fusarium mycotoxins enniatins and beauvericin cause mitochondrial

dysfunction by affecting the mitochondrial volume regulation, oxidative

phosphorylation and ion homeostasis.

Tonshin AA, Teplova VV, Andersson MA, Salkinoja-Salonen MS.

http://www.ncbi.nlm.nih.gov/pubmed/20621153

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State

University, Moscow RU-119899, Russia; Department of Food and Environmental

Sciences, Microbiology, University of Helsinki, Viikki Biocenter 1, POB 56,

Helsinki 00014, Finland.

Abstract

The mechanisms of cell toxicity of mycotoxins of the enniatin family produced by

Fusarium sp. enniatin B, a mixture of enniatin homologues (3% A, 20% A(1), 19%

B, 54% B1) and beauvericin, were investigated. In isolated rat liver

mitochondria, exposure to submicromolar concentrations of the enniatin

mycotoxins depleted the mitochondrial transmembrane potential, uncoupled

oxidative phosphorylation, induced mitochondrial swelling and decreased calcium

retention capacity of the mitochondria. The mitochondrial effects were strongly

connected with the potassium (K(+)) ionophoric activity of the enniatins. The

observed enniatins induced K(+) uptake by mitochondria. This shows that the

enniatins acted as ionophores highly selective for potassium ions. The effects

were observed in potassium containing media whereas less or no effect remained

to be observed when K(+) was partially or totally replaced by isomolar

concentrations of Na(+). The rank order of enniatin induced mitochondrial

impairment was