Re: found some interesting studies on RADS and other lung diseases

August 6, 2010

Osisposis,

I have read the article you sent " Asthma, COPD, RADS, MCS and Company: Diseases

of Chemical Sensing? "

While the article is quite complicated the ending sentence is the one making

most sense for me:

Exposures to high levels of TRPA1 agonists, including chlorine and aldehydes,

often induce reactive airways dysfunction syndrome (RADS) (23, 106, 115). RADS

is characterized by asthma-like symptoms such as cough, wheezing, chest

tightness, and dyspnoea and heightened sensitivity to chemical and physical

stimuli, including the initial sensitizing stimulus (23). The multiple chemical

sensitivity of TRPA1 can readily explain the broad chemical sensitivity observed

in RADS patients. An initial chemical sensory challenge and tissue injury may

sensitize TRPA1 channels through inflammatory signaling pathways, thereby

establishing prolonged hypersensitivity to multiple reactive chemicals (7, 12,

36, 57). The role of TRPA1 in chemical hypersensitivity may extend to other less

clearly defined conditions, including sensory hyperreactivity (SHR) and multiple

chemical sensitivity (MCS) (35, 91). RADS and related conditions are only

partially responsive to the therapeutic interventions developed for the

treatment of asthma. TRPA1 antagonists may be useful for blocking the

exaggerated chemosensory responses accompanying these conditions. Postexposure

treatment with TRP channel antagonists may reduce sensory irritation and,

potentially, prevent adverse long-term health effects elicited by neurogenic

inflammatory mechanisms.

However, in the references i came upon this article which gave me some hope that

my cough variant asthma is not an actual asthma but RADS and according to the

authors might disappear in a few years....

http://chestjournal.chestpubs.org/content/88/3/376

However, the chestjournal article suggests that RADS is non immunological

nature, which contradicts with the inflammation theory of the " Asthma, COPD,

RADS, MCS and Company: Diseases of Chemical Sensing? " article.

Correct me if i am wrong....even though it is not as important as long as it

will go away...I am not a scientist, just curious mind, so keep your

explanations simple.

>

> Which agents cause reactive airways dysfunction syndrome (RADS)? A systematic

review

> notice dust,silo fungus is listed.

>

> http://occmed.oxfordjournals.org/cgi/content/full/58/3/205

>

> abstract cited

>

> Sensory Detection and Responses to Toxic Gases

>

> http://pats.atsjournals.org/cgi/content/abstract/7/4/269

>

> notice the term " high level chemical exposures "

>

> Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex

Control

> Asthma, COPD, RADS, MCS and Company: Diseases of Chemical Sensing?

> full text

> http://physiologyonline.physiology.org/cgi/content/full/23/6/360#SEC6

>

> cited abstract

> http://physiologyonline.physiology.org/cgi/content/abstract/23/6/360

>

> Nasal chemosensory cells use bitter taste signaling to detect irritants and

bacterial signals

> http://www.pnas.org/content/107/7/3210.abstract

>

August 7, 2010

sorry, I dont have the answer, was wondering myself.

I meant to spend some time with this and see if I could find some answers myself

but got sidetracted.

I do fell that asthma and RADS are different, but it appears that so far they

are looked at as being pretty much the same thing.

one reason may be because to deturmine RADS you would have to basicly be exposed

to a harmful substance and alot of doctors aren't going to do that.

I think the caugh with RADS and the continueing closeing of with the airways

(some times to a very scary level) is different than at least some other lung

effects I have, and what I thought asthma meant.

I can see where RADS may not be so much based on inflammatory reaction for one

reason because when the iraways close up that quickly and to the extent they do,

it seem kindof hard to related inflammation as the cause or sole cause.

I can reconize at least 3 different things as far as lung reactions I have, I

can have basic inflammation without noticeable other reactions, I get to

breathing really hard with exertion and wheeze alot but I'm still getting a

fairly desent amount of air into the airways altough I can fell a little

restriction going on it doesn't proceed to closeing up the airways so bad that I

cant

get a breath like what happens when I get a re-exposure to chemical's and

things that in my view seem to mostly tied with VOC's, fumes, gas type exposures

and what I see as RADS.

I've stated before that I didn't think mycotoxins caused what at the time was

often refered to as MCS, however I, based on my own reactions, was including

what might be RADS vs inflammation and or asthma effects, as part of the MCS or

what I usually called a chemical reaction because RADS is a chemical reaction

but not everyone has it or those type of symptoms.sorry if I confuseing you,

it is complacated and I try to uncomplacate things for myself as well as others

but it's hard to do sometimes.

I fell that mycotoxins cause inflammation and damage to tissues and organs, but

as far as what I can deturmine from what I'm almost possative from a few

actcidental re-exposures to my first home and

that at least some mycotoxins do not cause the same effects to the lungs, or

possably RADS like other fumes,gasses,VOC's cause.

if I do have RADS and I'm pretty sure of that, it was gotten from my second

exposure in second home with had a very bad moisture problem and maybe a much

higher VOC exposure plus there were many other things involved that were

offgassing alot of chemicals.

I also know that several asthma inhalers didn't help me with the RADS

symptoms.

humm, I can say that with time and advoidance the intencity of my RADS reactions

SEEM to have mellowed out somewhat,overall,and the other bodily effects that go

along with this overall SEEM to have mellowed out a little, maybe, I say maybe

because it's just hard to

actually deturmine if it's really mellowed out or weither it's just because I

dont deal with it in a chronic way because of advoidance.

I still can have some very bad RADS reactions,and the effects to the rest of the

body can be very bad too. but there has been some change,

maybe it's mostly based on my overall level of tolerance improveing to some

degree.

I do fell that if I had to spend much time in the real world, I could go right

back to where I started as far as the intencity of these reactions and I dont

want to even go there ever again.

so I kindof think that in a way as reopening old wounds, like if you

had once broke a toe than rebreak it, the intencity of pain comes right back. I

dont think I could servive another exposure in a WDB.

I do think that even with RADS there would be levels of damage where some may

improve more than others with practiceing advoidance of chemicals in all forms,

so dont give up. at least I can, here in my own little world fell fairly decent

most of the time.

and I have improved to some level overall because I can get out in the real

would without suffering as bad as I used to.

but we live and learn, not long ago I desided I would dye my hair,

my daughter pick up the dye for me. we where outside when she put it on and the

minute she started the coughs and airways closeing up began and just continued

to get worse and my heart was beating hard and my loss of balance that is bad

anyway became severe and we had to just wash it out, I couldn't take it, and I

was outside and the wind was blowing and I was faceing the wind but I still just

couldn't take it.

it was dumb to even try,but I guess you live and learn.

>

> Osisposis,

> I have read the article you sent " Asthma, COPD, RADS, MCS and Company:

Diseases of Chemical Sensing? "

> While the article is quite complicated the ending sentence is the one making

most sense for me:

> Exposures to high levels of TRPA1 agonists, including chlorine and aldehydes,