SENSORY NERVE FIBERS,NOCICEPTORS

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TRPM8 Mechanism of Cold Allodynia after Chronic Nerve Injury

Cold allodynia is pathological pain induced by innocuous cold.

The pain is intractable and often occurs in patients with complex regional pain

syndrome; approximately 80% of these patients suffer from cold allodynia (Kemler

et al., 2000). Cold allodynia is also present in other disease conditions such

as fibromyalgia and diabetic neuropathy (Tahmoush et al., 2000; Vinik, 2004).

http://www.jneurosci.org/cgi/content/full/27/50/13680

Variable Threshold of Trigeminal Cold-Thermosensitive Neurons Is Determined by a

Balance between TRPM8 and Kv1 Potassium Channels

http://www.jneurosci.org/cgi/content/abstract/29/10/3120