Air pollution: mechanisms of neuroinflammation and CNS disease.

[Guest guest]

Air pollution: mechanisms of neuroinflammation and CNS

disease.

Trends Neurosci. 2009 Sep;32(9):506-16. Epub 2009 Aug

26.

Block ML, Calderón-Garcidueñas L.

Department of Anatomy and

Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA

23298, USA. MBlock@...

Abstract

Air pollution has been implicated as a chronic source of neuroinflammation

and reactive oxygen species (ROS) that produce neuropathology and central

nervous system (CNS) disease. Stroke incidence and Alzheimer's and Parkinson's

disease pathology are linked to air pollution. Recent reports reveal that air

pollution components reach the brain; systemic effects that impact lung and

cardiovascular disease also impinge upon CNS health. While mechanisms driving

air pollution-induced CNS pathology are poorly understood, new evidence suggests

that microglial activation and changes in the blood-brain barrier are key

components. Here we summarize recent findings detailing the mechanisms through

which air pollution reaches the brain and activates the resident innate immune

response to become a chronic source of pro-inflammatory factors and ROS,

culminating in CNS disease.

 

Full Text: 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743793/pdf/nihms132349.pdf

[Guest guest]

a: This is a very important concept for all to grasp. I am in constant

contact with Dr. Calderon-Garciduenas. Her research has clearly shown that in

humans, toxins reach the CNS via two pathways: systemic circulation and the

olfactory tract. This paper is a must read for all.

Jack Thrasher, Ph.D.

Toxicologist, Immunotoxicologist, Fetal toxicologist

Cell - 575-937-1150 Cell-Thrasher

Crawley, M.ED., LADC

Trauma Specialist

Cell -775-309-3994

www.drthrasher.org

CC: jeaninem660@...

From: kmtown2003@...

Date: Sat, 25 Dec 2010 13:52:46 -0800

Subject: [] Air pollution: mechanisms of neuroinflammation and CNS

disease.

Air pollution: mechanisms of neuroinflammation and CNS

disease.

Trends Neurosci. 2009 Sep;32(9):506-16. Epub 2009 Aug

26.

Block ML, Calderón-Garcidueñas L.

Department of Anatomy and

Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA

23298, USA. MBlock@...

Abstract

Air pollution has been implicated as a chronic source of neuroinflammation

and reactive oxygen species (ROS) that produce neuropathology and central

nervous system (CNS) disease. Stroke incidence and Alzheimer's and Parkinson's

disease pathology are linked to air pollution. Recent reports reveal that air

pollution components reach the brain; systemic effects that impact lung and

cardiovascular disease also impinge upon CNS health. While mechanisms driving

air pollution-induced CNS pathology are poorly understood, new evidence suggests

that microglial activation and changes in the blood-brain barrier are key

components. Here we summarize recent findings detailing the mechanisms through

which air pollution reaches the brain and activates the resident innate immune

response to become a chronic source of pro-inflammatory factors and ROS,

culminating in CNS disease.

Full Text:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743793/pdf/nihms132349.pdf

[Guest guest]

GOOD FINE k. from my understanding theres two the ways the csf can be affected

through the nasal route, the myelin sleath that comes down over your forhead can

get damaged, and CSF through the dura matter, and theres a place where CSF flows

in one direction cant recall the name, medialla or something, mabye this article

has it and I'm rusty on this, but there can be sort of a break down there and

csf can back flow into it , it's located somewhere in the back of the head.

one or both of these ways seemed to be a very good possablity with what happened

to me but I think that because of the attack on the rest of my body that was

equally severe, I also got attack to the brain by BBB breakdown at the same

time.

in my first home exposure none of these routes were passed in a serious way like

that but I probably had some seepage through the BBB.

the inflammation that I suffered in my spinal cords,back pain was intence in

that house, and it made my whole back side very sore and stiff but it seemed to

pretty well set at the back of my neck and

was probably working on my BBB.

while I had stuffy nose and some bloody noses, sinus discomfort, it was nothing

like the second house caused.

>

>

> Air pollution: mechanisms of neuroinflammation and CNS

> disease.

>

> Trends Neurosci. 2009 Sep;32(9):506-16. Epub 2009 Aug

> 26.

> Block ML, Calderón-Garcidueñas L.

> Department of Anatomy and

> Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA

> 23298, USA. MBlock@...

>

> Abstract

>

> Air pollution has been implicated as a chronic source of neuroinflammation

> and reactive oxygen species (ROS) that produce neuropathology and central

> nervous system (CNS) disease. Stroke incidence and Alzheimer's and Parkinson's

> disease pathology are linked to air pollution. Recent reports reveal that air

> pollution components reach the brain; systemic effects that impact lung and

> cardiovascular disease also impinge upon CNS health. While mechanisms driving

> air pollution-induced CNS pathology are poorly understood, new evidence

suggests

> that microglial activation and changes in the blood-brain barrier are key

> components. Here we summarize recent findings detailing the mechanisms through

> which air pollution reaches the brain and activates the resident innate immune

> response to become a chronic source of pro-inflammatory factors and ROS,

> culminating in CNS disease.

>  

> Full Text: 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743793/pdf/nihms132349.pdf

>