Building-associated neurological damage modeled in human cells: a mechanism of neurotoxic effects by exposure to mycotoxins in the indoor environment.

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Building-associated neurological damage modeled in human cells: a

mechanism of neurotoxic effects by exposure to mycotoxins in the indoor

environment.

Karunasena E, Larrañaga MD, Simoni JS, DR, Straus DC.

Mycopathologia. 2010 Dec;170(6):377-90. Epub 2010 Jun 13.

Department

of Animal & Food Sciences, Texas Tech University, Lubbock, TX 79409, USA.

enusha.karunasena@...

Abstract

Damage to human neurological system cells resulting from exposure to

mycotoxins confirms a previously controversial public health threat for

occupants of water-damaged buildings. Leading scientific organizations disagree

about the ability of inhaled mycotoxins in the indoor environment to cause

adverse human health effects. Damage to the neurological system can result from

exposure to trichothecene mycotoxins in the indoor environment. This study

demonstrates that neurological system cell damage can occur from satratoxin H

exposure to neurological cells at exposure levels that can be found in

water-damaged buildings contaminated with fungal growth. The constant activation

of inflammatory and apoptotic pathways at low levels of exposure in human brain

capillary endothelial cells, astrocytes, and neural progenitor cells may amplify

devastation to neurological tissues and lead to neurological system cell damage

from indirect events triggered by the presence of trichothecenes.

PMID: 20549560 [PubMed - in process]