I think voriconazole cured a middle ear infection I had for almost 3 years

[Guest guest]

I had on and off pain on the eardrum, eustachain tubes, etc for nearly 3 years.

Drs thought I may have to get tubes in my eardrums to release the pressure (and

get a culture). Both fluconazole and itraconazole did not fix the problem.

48h after starting voriconazole it went away and hasnt reappeared yet, 10 days

later. I still have 20 days @ 200mg BID, with one month refill possible. Also my

AST liver enzyme went down to normal - after being constantly elevated for that

long. Needless to say I'm very excited about this - it looks like I caught a

fungal infection almost 3 years ago by sleeping with my face directly on a

(moldy?) carpet.

I'm thinking of trying posiconazole and caspofungin as well. I know my insurance

will start to complain - especially that I'm starting IV abx for lyme.

voriconazole is 2700$/month at costco. Thankfully my insurance covered most of

it. Thanks to my awesome hollistic Dr who give me the drugs I want.

Just wanted to give a " testimonial " . Of course I have no financial ties to

Pfizer or any other Big Pharma compagnies.

[Guest guest]

if you were to bet on which fungus was causing the infection, perhaps using

http://www.mediafire.com/?iwctvolx4vs97gr

Aureobasidium pullulans 6900 spore equivalent/mg of dust

Fusarium solani 1400

Cladosporium cladosporioides 1 410

Wallemia sebi 110

Cladosporium herbarum 94

Stachybotrys chartarum 70

Cladosporium cladosporioides 2 54

Cladosporium sphaerospermum 54

Epicoccum nigrum 53

etc

Total: 9,294

what would you bet on?

[Guest guest]

Thanks for the info. my ears have been hurting off and on, mostly on, sence my

exposure, some time the pressure and pain gets pretty bad, did you also have

ringing and humming problems?

>

> I had on and off pain on the eardrum, eustachain tubes, etc for nearly 3

years. Drs thought I may have to get tubes in my eardrums to release the

pressure (and get a culture). Both fluconazole and itraconazole did not fix the

problem.

>

> 48h after starting voriconazole it went away and hasnt reappeared yet, 10 days

later. I still have 20 days @ 200mg BID, with one month refill possible. Also my

AST liver enzyme went down to normal - after being constantly elevated for that

long. Needless to say I'm very excited about this - it looks like I caught a

fungal infection almost 3 years ago by sleeping with my face directly on a

(moldy?) carpet.

>

> I'm thinking of trying posiconazole and caspofungin as well. I know my

insurance will start to complain - especially that I'm starting IV abx for lyme.

voriconazole is 2700$/month at costco. Thankfully my insurance covered most of

it. Thanks to my awesome hollistic Dr who give me the drugs I want.

>

> Just wanted to give a " testimonial " . Of course I have no financial ties to

Pfizer or any other Big Pharma compagnies.

>

[Guest guest]

I'm gonna place my bet on Fusarium solani.

Itraconazole (and of course fluconazole) appear to have negligible activity

against Fusarium species. In fact most of these species are even moderately

susceptible or resistant to amphotericin B. However voriconazole is mostly

effective.

Specifically for Fusarium solani, in

http://aac.asm.org/cgi/content/short/49/3/945 their multi-drug resistant

fusarium solani species was not affected by neither amphotericin B nor

voriconazole, however their normal fusarium solani species was taken care of by

both amphotericin B and voriconazole.

[Guest guest]

did you test positive on a culture for fusarium in your nasal/ear fluids

or just try the voriconizole and it helped? thanks, sue

>I'm gonna place my bet on Fusarium solani.

>

>Itraconazole (and of course fluconazole) appear to have negligible

>activity against Fusarium species. In fact most of these species are

>even moderately susceptible or resistant to amphotericin B. However

>voriconazole is mostly effective.

>

>Specifically for Fusarium solani, in http://aac.asm.org/cgi/content/

>short/49/3/945 their multi-drug resistant fusarium solani species was

>not affected by neither amphotericin B nor voriconazole, however their

>normal fusarium solani species was taken care of by both amphotericin B

>and voriconazole.

>

[Guest guest]

Jeanine I did have some ringing and humming but nothing out of control.

Sue isnt clear from my post that I did not get a positie culture?? In fact 2-3

weeks ago the pain was terrible (just before I start the voriconazole) and my

university's Drs said the eardrum looked like it was about to burst. Then wanted

me to go see an otolaryngologist to put tubes in my ears and hence get a

culture. I refused because sometimes it causes hearing loss. Instead I convinced

another dr to prescribe voriconazole (without mentionning my ear infection!).