Re: CBRNE - T-2 Mycotoxins: Differential Diagnoses & Workup

[Guest guest]

I wonder about this toxin and what if you were exposed to it in your WDB but you

took a shower every day, would this keep you from getting alot of blisters? I

had only one blister on my neck area while exposed

.. not sure if that was what it was from. it damaged the skin around it

and still looks pretty much the same. it's weird looking, the tissue under the

skin around the scar seems to have cracked,seperated, and dried that way, with a

red color to it. a fairly large spot on my neck. anybody else?

>

> Workup

> Laboratory Studies

> Updated: Aug 19, 2008

>

> http://emedicine.medscape.com/article/830892-diagnosis

>

> With growing health concerns related to mold exposures and its related

morbidity and mortality, devices have been developed to detect environmental

mycotoxin exposure. To date, no data exist to differentiate the expected

background levels of these substances from potential toxic and/or intentional

contamination.

>

> T-2 toxin is rapidly metabolized to HT-2, T2-triol, and T-2 tetraol within

hours after exposure. While these toxin metabolites may be detected in body

fluids, tissue, and stomach contents for up to 28 days following exposure, these

results are unlikely to be available to help the medical provider manage the

patient. Newer urine assays detect T-2 metabolite for up to one week after

exposure. Definitive diagnosis must be made in a reference laboratory using

thin-layer or gas-liquid chromatography, mass or nuclear magnetic resonance

spectrometry, radioimmunoassay, and enzyme-linked immunosorbent assay (ELISA)

techniques.

>

> •Perform immediate

[Guest guest]

T-2 Toxin has been showy only once as a contaminant of damp indoor spaces. The

results of the report by Tuomi et al (see below) have not been, to my knowledge,

confirmed by others. T-2 toxins are produced by Fusarium species and

contaminated grains. I do not believe that there is an ELISA test for detecting

this mycotoxin in human urine. There are such tests available for feed and live

stock. However these tests are not used for human testing nor are the

laboratories CLIA licensed.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC101430/pdf/am001899.pdf

The only tests currently available are those of RealTime laboratories and the

test for macrocyclic mycotoxins.

I looked at the e-medicine blurb from which you obtained the information. The

information in the e-medicine is largely drawn from Wallace's review regarding

the toxicology of T-2 toxin.

Jack-Dwayne: Thrasher, Ph.D.

Toxicologist/Immunotoxicologist/Fetaltoxicologist

www.drthrasher.org

toxicologist1@...

Off: 916-745-4703

Cell: 575-937-1150

L. Crawley, M.ED., LADC

Trauma Specialist

sandracrawley@...

916-745-4703 - Off

775-309-3994 - Cell

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