Neurotoxicity of Fungal Volatile Organic Compounds

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Neurotoxicity of Fungal Volatile Organic Compounds in Drosophila melanogaster

Arati A. Inamdar1, Prakash Masurekar and Joan Wennstrom

+ Author Affiliations

Department of Plant Biology and Pathology, Rutgers, The State University of New

Jersey, New Brunswick, New Jersey 08901

1To whom correspondence should be addressed at 59, Dudley Road, Foran Hall, Room

291D, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901. Fax:

(732) 932-9441. E-mail: inamdar@....

Received February 18, 2010.

Accepted July 6, 2010.

Abstract

Many volatile organic compounds (VOCs) are found in indoor environment as

products of microbial metabolism. In damp indoor environments, fungi are

associated with poor air quality. Some epidemiological studies have suggested

that microbial VOCs have a negative impact on human health. Our study was

designed to provide a reductionist approach toward studying fungal VOC–mediated

toxicity using the inexpensive model organism, Drosophila melanogaster, and pure

chemical standards of several important fungal VOCs. Low concentrations of the

following known fungal VOCs, 0.1% of 1-octen-3-ol and 0.5% of 2-octanone; 2,5

dimethylfuran; 3-octanol; and trans-2-octenal, caused locomotory defects and

changes in green fluorescent protein (GFP)- and antigen-labeled dopaminergic

neurons in adult D. melanogaster. Locomotory defects could be partially rescued

with L-DOPA. Ingestion of the antioxidant, vitamin E, improved the survival span

and delayed the VOC-mediated changes in dopaminergic neurons, indicating that

the VOC-mediated toxicity was due, in part, to generation of reactive oxygen

species.

Key words

dopamineDrosophila melanogasterfungiParkinson's diseasesick building

syndromevolatile organic compounds

http://toxsci.oxfordjournals.org/content/117/2/418.abstract

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Thanks Sharon, I was supprized to find it. if anyone get's the full text please

send to me.

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> Another great find, Jeanine!

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> Sharon K

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> In a message dated 12/23/2010 7:44:56 A.M. Pacific Standard Time,

> jeaninem660@... writes:

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> _http://toxsci.oxfordjournals.org/content/117/2/418.abstract_

> (http://toxsci.oxfordjournals.org/content/117/2/418.abstract)

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