Re: Spam[4] I think voriconazole cured a middle ear infection I had for almost 3 years

[Guest guest]

what does voriconazole do that less expensive antifungals like the

ketaconazole oral my son is taking with no positive effects, 200 mg per

day, has been on for a couple months, will do another week of this

ineffective trial and then on to the next thing.... other than candida,

no fungal infections have actually been cultured from his body fluids.

sue v.

I had on and off pain on the eardrum, eustachain tubes, etc for nearly 3

>years. Drs thought I may have to get tubes in my eardrums to release the

>pressure (and get a culture). Both fluconazole and itraconazole did not

>fix the problem.

>

>48h after starting voriconazole it went away and hasnt reappeared yet,

>10 days later. I still have 20 days @ 200mg BID, with one month refill

[Guest guest]

the spectrum of action of ketaconazole and fluconazole are pretty limited.

Itraconazole has a better spectrum, but caps have little bioavailibility.

Itraconazole oral solution is good. Still many fungi are resistant to these, so

just like antibiotics one uses 2nd generation triazole like voriconazole or

posaconazole.

Amphotericin B was the drug of choice for systemic infection, but is more toxic

on the liver and for most species does not beat vorico.

Another category worth a try are the echinocandins like caspofungin. Actually

vorico and caspofungin can be combined for infection that have reached the CNS.

Testing is extremely primitive - unless your son is within imminent death from

sepsis, the vast majority of doctors wont consider a systemic fungal infection

other than candida-->fluconazole or something like that. You have to find a dr

that will let you try what you want, or order from overseas (which I regularly

do).

That being said, if your son is under 18 there might be issues with those drugs,

do your research on that.

>

> what does voriconazole do that less expensive antifungals like the

> ketaconazole oral my son is taking with no positive effects, 200 mg per

> day, has been on for a couple months, will do another week of this

> ineffective trial and then on to the next thing.... other than candida,

> no fungal infections have actually been cultured from his body fluids.

>

> sue v.

>

>

> I had on and off pain on the eardrum, eustachain tubes, etc for nearly 3

> >years. Drs thought I may have to get tubes in my eardrums to release the

> >pressure (and get a culture). Both fluconazole and itraconazole did not

> >fix the problem.

> >

> >48h after starting voriconazole it went away and hasnt reappeared yet,

> >10 days later. I still have 20 days @ 200mg BID, with one month refill

>

[Guest guest]

thanks, he is 21 yo. siue

>the spectrum of action of ketaconazole and fluconazole are pretty

>limited. Itraconazole has a better spectrum, but caps have little

>bioavailibility. Itraconazole oral solution is good. Still many fungi

>are resistant to these, so just like antibiotics one uses 2nd generation

>triazole like voriconazole or posaconazole.

>

snip