CFS, CSF,

[Guest guest]

WOW,this is very interesting. I have a felling the tables are about to turn.

http://www.sciencedaily.com/releases/2011/02/110223171235.htm

Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease

from Chronic Fatigue Syndrome

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017287

1. E Schutzer, E Angel, Tao Liu, Athena A Schepmoes, Therese R

Clauss, N Adkins, G Camp, Bart K Holland, Jonas Bergquist,

K Coyle, D , A Fallon, H Natelson. Distinct

Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from

Chronic Fatigue Syndrome. PLoS ONE, 23 Feb 2011

DOI: 10.1371/journal.pone.0017287

Example of proteins in common and elevated in abundance in the two disease

conditions, compared to normal, but at different levels.An illustration, where

the same proteins are elevated in abundance in both conditions, but at different

magnitudes, is provided by inspection of proteins in the complement system. This

is of interest because both syndromes may be triggered by infections (nPTLS in

all cases by B. burgdorferi; many CFS cases by one or more microbes yet to be

identified).

Table S6. Pathways significantly enriched by proteins identified only in the

pooled sample proteome for CFS patients.

Ingenuity Canonical Pathways

-log(p-value)

CDK5 Signaling

4.06

Cardiac beta-adrenergic Signaling

3.40

Dopamine Receptor Signaling

3.30

Protein Kinase A Signaling

2.58

Relaxin Signaling

2.21

Cellular Effects of Sildenafil (Viagra)

2.07

Clathrin-mediated Endocytosis Signaling

2.00

cAMP-mediated Signaling

2.00

Breast Cancer Regulation by Stathmin1

1.88

Sphingosine-1-phosphate Signaling

1.84

Hepatic Fibrosis / Hepatic Stellate Cell Activation

1.70

α-Adrenergic Signaling

1.68

Valine, Leucine and Isoleucine Degradation

1.67

Production of Nitric Oxide and Reactive Oxygen Species in Macrophages

1.66

IL-1 Signaling

1.61

Leptin Signaling in Obesity

1.56

G-Protein Coupled Receptor Signaling

1.56

Role of NFAT in Cardiac Hypertrophy

1.56

Gα12/13 Signaling

1.52

Actin Cytoskeleton Signaling

1.47

IL-8 Signaling

1.43

CREB Signaling in Neurons

1.43

Synaptic Long Term Potentiation

1.36

CXCR4 Signaling

1.31