Saliva Secretory IgA Antibodies Against Molds and Mycotoxins in Patients Exposed

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Saliva Secretory IgA Antibodies Against Molds and Mycotoxins in Patients Exposed

to Toxigenic Fungi

Authors: Aristo Vojdani a; Albert Kashanian a; Elroy Vojdani a; W.

b

Affiliations: a Section of Neuroimmunology, Immunosciences Lab., Inc.,

Beverly Hills, California, USA

b Medical Center for Immune & Toxic Disorders, Spring, Texas, USA

DOI: 10.1081/IPH-120026444

Publication Frequency: 4 issues per year

Published in: Immunopharmacology and Immunotoxicology, Volume 25, Issue 4

December 2003 , pages 595 - 614

Subjects: Immunology; Pharmacology; Toxicology;

Formats available: HTML (English) : PDF (English)

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Abstract

Upper respiratory exposure to different environmental antigens results first in

the activation of mucosal immunity and production of IgA antibodies in different

secretions including saliva. Despite this there is no study, which addresses

secretory antibodies against molds and mycotoxins. The purpose of this study was

to evaluate mold-specific salivary IgA in individuals exposed to molds and

mycotoxins in a water-damaged building environment. Saliva IgA antibody levels

against seven different molds and two mycotoxins were studied in 40 patients

exposed to molds and in 40 control subjects. Mold-exposed patients showed

significantly higher levels of salivary IgA antibodies against one or more mold

species. A majority of patients with high IgA antibodies against molds exhibited

elevation in salivary IgA against mycotoxins, as well. These IgA antibodies

against molds and mycotoxins are specific, since using molds and mycotoxins in

immune absorption could reduce antibody levels, significantly. Detection of high

counts of molds in water-damaged buildings, strongly suggests the existence of a

reservoir of mold spores in the environment. This viable microbial activity with

specific mold and mycotoxin IgA in saliva may assist in the diagnosis of mold

exposure. Whether mold and mycotoxin specific IgA antibodies detected in saliva

are indicative of the role of IgA antibodies in the late phase of type-1

hypersensitivity reaction or in type-2 and type-3 delayed sensitivities is a

matter that warrants further investigation.

Keywords: Molds; Mycotoxins; Saliva; Secretory IgA; Water-damaged building

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