fungal rhinosinusitis,fungal infection CNS,

[Guest guest]

well, I have high hopes for the antifungal nasal spray, I hope it makes my

polops go away and allows some healing in the sinus>brain area. gezz, was trying

to find a compounding pharmacy around here,

the minute I mentioned antifungal things became a little different story. I'm

going to get pretty upset if I cant get this done in my area, this is crazy. I

wonder how my medicad ins. is going to take this.? I have a felling it's going

to be a battle.

Fungal infections of the CNS

http://yassermetwally.wordpress.com/cns-infection/fungal-infections-of-the-cns/

Fungal infections of the central nervous system (CNS) are being increasingly

diagnosed both in immunocompromised and immunocompetent individuals. Sinocranial

aspergillosis is more frequently described from countries with temperate

climates, more often in otherwise immunocompetent individuals.

(maybe some WDB's are very closely like these temperate climates)

Most of the fungi are aerosolized and inhaled and initiate a primary pulmonary

infection which is usually self-limited. Hematogenous dissemination may follow

the initial infection, with subsequent involvement of the CNS. Local extension

from paranasal sinuses, ear and orbit [5] and rarely trauma [6] also provide the

route to intracranial spread.

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Vojnosanit Pregl. 2010 Mar;67(3):209-12.

[impact of rhinosinusal polyposis on CT score in patients with chronic

rhinosinustis]

[Article in Serbian]

Dudvarski Z, Janoseviæ L, Pender I, Djukiæ V, Jesiæ S, Dimitrijeviæ M, Arsoviæ

N.

Klinicki centar Srbije, Institut za otorinolaringologiju i maksilofacijalnu

hirurgiju, Beograd, Srbija. dudvarski@...

Abstract

BACKGROUND/AIM: Chronic sinusitis is a disease characterized with mucosal

inflammation of nasal and paranasal sinuses for at least 12 weeks. In order to

assess the extent and severity of inflammatory changes in paranasal sinuses CT

score according to Lund-Mackay is the most commonly used. Recent studies show

the possibility of existing different subtipes of chronic rhinosinusitis,

pointing out the presence of nasal polyps and their influence on the severity of

chronic rhinosinusitis. The aim of this research was to examine the influence of

sinonasal polyposis on the extensity of inflammatory changes on computerized

tomography (CT), evaluated by the Lund-Mackay CT score. METHODS: A prospective

study compared the Lund-Mackay CT score values between the patients with chronic

rhinosinusitis associated with nasal polyps and those without them. We

determined mean values of the total CT score in both groups of the patients, as

well as mean values of CT score for each group of sinuses and ostiomeatal

complexes. RESULTS: The study included 90 patients, 47 males and 43 females,

45-year old on average, diagnosed with chronic rhinosinusitis on the basis of

diagnostic algorithm. The group with uncomplicated chronic rhinosinusitis

(without nasal polyps) consisted of 30 patients and the group with complicated

chronic rhinosinusitis (with nasal polyps) of 60 patients. Observing these two

groups of patients revealed statistically highly important intergroup difference

in CT score for each group of sinuses and ostiomeatal complexes. The mean value

of total CT score in the group with uncomplicated chronic rhinosinusitis was

4.37 while in the group with complicated chronic rhinosinusitis it was 16.05 (p

< 0.01). CONCLUSION: Chronic rhinosinusitis complicated by sinonasal polyposis

is characterized with more extensive inflammatory changes on CT and,

consequently, with higher CT score for each group of sinuses and ostiomeatal

complexes, as well as higher total CT score.

PMID: 20361694 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/20361694