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The Use of Isolated Human Lymphocytes in Mycotoxin

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The Use of Isolated Human Lymphocytes in Mycotoxin

Cytotoxicity Testing

All mycotoxin standards evaluated in this study were toxic to the human

lymphocytes

The variation of the individual's lymphocytes sensitivity to the tested

mycotoxins in this study

(DON, FB1 and OTA) was found to be negligible, as no significant difference was

observed among the

three donors. However, potential differences in in vivo exposures of lymphocytes

to toxins must take

into account individual differences such as the uptake, metabolism, combined

effects of the toxins, the extent of exposure (duration or dose) and other

factors such as age, gender, nutritional status, as well

as the physiological state of the affected individuals.

http://mdpi.org/ijms/papers/i9081515.pdf

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