fungal infection, mucosal injury,thats what happens

[Guest guest]

and you dont have to be immunocompromized for that.

Mucosal injury caused by viral infection, allergy, or other factors compromises

the mucociliary barriers designed to maintain sterility of the middle ears,

paranasal sinuses, and lungs.

Chronic invasive fungal sinusitis can occur not only in immunocompromised

patients but also in patients who are immunologically normal. Most of these

latter patients have chronic sinusitis and nasal polyposis. Causative organisms

include the dematiaceous molds noted above; the condition is known as

phaeohyphomycosis. Dense masses of fungal elements resembling mycetoma are

found, but there is also invasion into the mucosa and then into bone. Patients

present with headache and localizing symptoms such as decreased vision and loss

of eye movement (orbital apex syndrome) or behavioral changes (mycetoma of the

frontal lobe).

INFECTIOUS DISEASE

CHAPTER TWO

Upper Respiratory Tract Infections and Other Infections of the Head and Neck

http://pathmicro.med.sc.edu/Infectious%20Disease/Upper%20respiratory%20tract.htm

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clinical data in patients support the concept that the degree of mucosal damage

is an important factor in determining the risk of invasive fungal infection

Mucosal Injury

The degree of mucosal injury is an independent risk factor for invasive fungal

infection. As noted above, in animal models, C tropicalis has a much greater

capacity than C albicans to invade the mucosal barrier. This difference is

responsible for C tropicalis having a greater propensity to cause systemic

candidiasis in patients receiving antileukemic regimens that cause greater

mucosal injury.[23,24] Clinical studies also show the degree of mucosal injury

to be a major influence on the risk of invasive fungal infection during

neutropenia.[25,26]

http://www.cancernetwork.com/display/article/10165/91823

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Compromise of the mucosal barrier can contribute to local invasion by colonizing

microorganisms and, subsequently, to systemic infection.

Infection and Mucosal Injury in Cancer Treatment

http://jncimono.oxfordjournals.org/cgi/content/abstract/2001/29/31

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