Adaptations to Resistance Training in Old (>80 y) Men

[Guest guest]

Members may enjoy reading:

Single Muscle Fiber Adaptations to Resistance Training in Old (>80 y)

Men: Evidence for Limited Skeletal Muscle Plasticity.

Am J Physiol Regul Integr Comp Physiol. 2008 Apr 30 [Epub ahead of

print] Links

Slivka D, Raue U, Hollon C, Minchev K, Trappe SW.

The purpose of this study was to investigate whole muscle and single

muscle fiber adaptations in very old men in response to progressive

resistance training (PRT). Six healthy independently living old men

(82+/-1 y; range 80-86 y, 74+/-4 kg) resistance trained the knee

extensors (3 sets, 10 repetitions) at ~70% one repetition maximum 3

days/wk for 12 wks. Whole thigh muscle cross-sectional area (CSA) was

assessed before and after PRT using computed tomography (CT). Muscle

biopsies were obtained from the vastus lateralis before and after the

PRT program. Isolated myosin heavy chain (MHC) I and IIa single

muscle fibers (n=267; 142 pre; 125 post) were studied for diameter,

peak tension, shortening velocity and power. An additional set of

isolated single muscle fibers (n=2215; 1202 pre; 1013 post) was used

to identify MHC distribution. One repetition maximum knee extensor

strength increased (p<0.05) 23+/-4 kg (56+/-4 to 79+/-7 kg; 41%).

Muscle CSA increased (p<0.05) 3+/-1 cm(2) (120+/-7 to 123+/-7 cm(2);

2.5%). Single muscle fiber contractile function and MHC distribution

were unaltered with PRT.

These data indicate limited muscle plasticity at the single fiber

level with a resistance-training program among the very old. The

minor increases in whole muscle CSA coupled with the static nature of

the myocellular profile indicate that the strength gains were

primarily neurological. These data contrast typical muscle responses

to resistance training in young (~20 y) and old (~70 y) humans and

indicate that the physiological regulation of muscle remodeling is

adversely modified in the oldest old. Key words: Sarcopenia, Aging,

Skeletal Muscle.

===================

Carruthers

Wakefield, UK

[Guest guest]

That is very interesting. I wonder what a longer term study might show?

After, say, 24, or 36, or 52 weeks, would we see some muscle fiber

growth, in which case we might see that muscle fibers would indeed

respond to training, but much more slowly than the neurological

response? Would the muscle growth start to become more like a youthful

response with continued training, overtaking the rate of neurological

improvement as it progressed? Or would we find that, at this advanced

age, neurological improvement is about the best, or perhaps 95%, of what

we can hope for in the long term also?

ph Preston

Leesburg, VA USA

(still 34 years away from 80, but looking for hope)

carruthersjam wrote:

>

> Members may enjoy reading:

>

> Single Muscle Fiber Adaptations to Resistance Training in Old (>80 y)

> Men: Evidence for Limited Skeletal Muscle Plasticity.

>

> Am J Physiol Regul Integr Comp Physiol. 2008 Apr 30 [Epub ahead of

> print] Links

>

> Slivka D, Raue U, Hollon C, Minchev K, Trappe SW.

>

> The purpose of this study was to investigate whole muscle and single

> muscle fiber adaptations in very old men in response to progressive

> resistance training (PRT). Six healthy independently living old men

> (82+/-1 y; range 80-86 y, 74+/-4 kg) resistance trained the knee

> extensors (3 sets, 10 repetitions) at ~70% one repetition maximum 3

> days/wk for 12 wks. Whole thigh muscle cross-sectional area (CSA) was

> assessed before and after PRT using computed tomography (CT). Muscle

> biopsies were obtained from the vastus lateralis before and after the

> PRT program. Isolated myosin heavy chain (MHC) I and IIa single

> muscle fibers (n=267; 142 pre; 125 post) were studied for diameter,

> peak tension, shortening velocity and power. An additional set of

> isolated single muscle fibers (n=2215; 1202 pre; 1013 post) was used

> to identify MHC distribution. One repetition maximum knee extensor

> strength increased (p<0.05) 23+/-4 kg (56+/-4 to 79+/-7 kg; 41%).

> Muscle CSA increased (p<0.05) 3+/-1 cm(2) (120+/-7 to 123+/-7 cm(2);

> 2.5%). Single muscle fiber contractile function and MHC distribution

> were unaltered with PRT.

>

> These data indicate limited muscle plasticity at the single fiber

> level with a resistance-training program among the very old. The

> minor increases in whole muscle CSA coupled with the static nature of

> the myocellular profile indicate that the strength gains were

> primarily neurological. These data contrast typical muscle responses

> to resistance training in young (~20 y) and old (~70 y) humans and

> indicate that the physiological regulation of muscle remodeling is

> adversely modified in the oldest old. Key words: Sarcopenia, Aging,

> Skeletal Muscle.

>

> ===================

> Carruthers

> Wakefield, UK

>

>

[Guest guest]

> >

> > Members may enjoy reading:

> >

> > Single Muscle Fiber Adaptations to Resistance Training in Old

(>80 y)

> > Men: Evidence for Limited Skeletal Muscle Plasticity.

> >

> > Am J Physiol Regul Integr Comp Physiol. 2008 Apr 30 [Epub ahead of

> > print] Links

> >

> > Slivka D, Raue U, Hollon C, Minchev K, Trappe SW.

> >

> > The purpose of this study was to investigate whole muscle and

single

> > muscle fiber adaptations in very old men in response to

progressive

> > resistance training (PRT). Six healthy independently living old

men

> > (82+/-1 y; range 80-86 y, 74+/-4 kg) resistance trained the knee

> > extensors (3 sets, 10 repetitions) at ~70% one repetition maximum

3

> > days/wk for 12 wks. Whole thigh muscle cross-sectional area (CSA)

was

> > assessed before and after PRT using computed tomography (CT).

Muscle

> > biopsies were obtained from the vastus lateralis before and after

the

> > PRT program. Isolated myosin heavy chain (MHC) I and IIa single

> > muscle fibers (n=267; 142 pre; 125 post) were studied for

diameter,

> > peak tension, shortening velocity and power. An additional set of

> > isolated single muscle fibers (n=2215; 1202 pre; 1013 post) was

used

> > to identify MHC distribution. One repetition maximum knee extensor

> > strength increased (p<0.05) 23+/-4 kg (56+/-4 to 79+/-7 kg; 41%).

> > Muscle CSA increased (p<0.05) 3+/-1 cm(2) (120+/-7 to 123+/-7 cm

(2);

> > 2.5%). Single muscle fiber contractile function and MHC

distribution

> > were unaltered with PRT.

> >

> > These data indicate limited muscle plasticity at the single fiber

> > level with a resistance-training program among the very old. The

> > minor increases in whole muscle CSA coupled with the static

nature of

> > the myocellular profile indicate that the strength gains were

> > primarily neurological. These data contrast typical muscle

responses

> > to resistance training in young (~20 y) and old (~70 y) humans and

> > indicate that the physiological regulation of muscle remodeling is

> > adversely modified in the oldest old. Key words: Sarcopenia,

Aging,

> > Skeletal Muscle.

> >

> > ===================