mucosal injury!

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NOTICE the VIP,IL17,TH TYPE1 TH TYPE 2 ,MUCOSAL CONNECTION, FUNGAL INFECTION,

Cutting Edge: Vasoactive Intestinal Peptide (VIP) Induces Differentiation of

Th17 Cells with a Distinctive Cytokine Profile

http://www.jimmunol.org/content/180/5/2772.abstract

http://www.nature.com/mi/journal/v2/n5/full/mi2009100a.html

Immunology: Cause of death matters

Brigitta Stockinger1

Top of pageAbstractThe process of programmed cell death can either induce

anti-inflammatory immune responses or actively promote inflammation. Whether the

dying cell is infected seems to govern which response is triggered. To deal with

invading pathogens efficiently, helper T cells of the adaptive immune system

differentiate to form distinct subsets of cells with specific immune functions.

Much work has been done on two such subsets, T helper type 1 and type 2 cells

(TH1 and TH2 cells).

http://www.nature.com/nature/journal/v458/n7234/full/458044a.html

Mice lacking the VIP gene show airway hyperresponsiveness and airway

inflammation, partially reversible by VIP

http://ajplung.physiology.org/content/291/5/L880.abstract

Mucosal Immunology 2, 403-411 (September 2009)

Th17 cells at the crossroads of innate and adaptive immunity against infectious

diseases at the mucosa

S A Khader, S L Gaffen and J K Kolls

AbstractT helper type 17 (Th17) cells are a distinct lineage of T cells that

produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the

role of Th17 cells in autoimmunity is well documented, there is growing evidence

that the Th17 lineage and other interleukin (IL)-17-producing cells are critical

for host defense against bacterial, fungal, and viral infections at mucosal

surfaces. Here we summarize recent progress in our understanding of the function

of IL-17-producing cells as a bridge between innate and adaptive immunity

against infectious diseases at the mucosa.

http://www.nature.com/mi/journal/v2/n5/full/mi2009100a.html