JAILMast cell activation syndrome: Proposed diagnostic criteria

[Guest guest]

http://www.jacionline.org/article/S0091-6749(10)01333-3/abstract?elsca1=etoc & els\

ca2=email & elsca3=0091-6749_201012_126_6 & elsca4=allergy

The term mast cell activation syndrome (MCAS) is finding increasing use as a

diagnosis for subjects who present with signs and symptoms involving the dermis,

gastrointestinal track, and cardiovascular system frequently accompanied by

neurologic complaints. Such patients often have undergone multiple extensive

medical evaluations by different physicians in varied disciplines without a

definitive medical diagnosis until the diagnosis of MCAS is applied. However,

MCAS as a distinct clinical entity has not been generally accepted, nor do there

exist definitive criteria for diagnosis. Based on current understanding of this

disease “syndrome†and on what we do know about mast cell activation and

resulting pathology, we will explore and propose criteria for its diagnosis. The

proposed criteria will be discussed in the context of other disorders involving

mast cells or with similar presentations and as a basis for further scientific

study and validation.

 

 

God Bless !!

dragonflymcs

Mayleen