Mold May Trigger Severe Asthma in Some Folks

[Guest guest]

Mold May Trigger Severe Asthma in Some Folks

http://www.medicinenet.com/script/main/art.asp?articlekey=117503

SOURCE: American Thoracic Society, news release, June 24, 2010

THURSDAY, June 24 (HealthDay News) -- Living in a home with high levels of mold

may increase the risk of severe asthma attacks in people with certain gene

variants, finds a new study.

" We found that the interaction between environmental mold exposure and certain

variants of chitinase genes were positively associated with severe asthma

exacerbations requiring hospitalization, " lead researcher Ann Wu, an assistant

professor at Harvard Medical School and Harvard Pilgrim Health Care Institute,

said in an American Thoracic Society news release.

Chitinases, which break down a component in fungi called chitin, are induced

during allergic inflammation. It's known that people with asthma have higher

expression of certain variants of chitinase.

In this study, Wu and colleagues analyzed data from the Childhood Asthma

Management Program, a trial that enrolled children between the ages of 5 and 12

with mild to moderate persistent asthma. The children's homes were classified as

having more or less than 25,000 mold colonies per gram of household dust. A

level greater than 25,000 is considered high for a home.

The researchers also conducted genetic tests on blood samples taken from the

children. They concluded that certain variants of the chitinase gene CHIT1,

along with exposure to high levels of mold, are associated with an increased

risk of severe asthma attacks.

The study, published online June 24 and in an upcoming print issue of the

American Journal of Respiratory and Critical Care Medicine, suggests that

chitinases may offer a target for new types of asthma treatments.

-- Preidt