Small fiber neuropathy in Charcot-Marie-Tooth disease

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I believe my legs get 53% colder then a normal person as well.

In a message dated 2/3/2010 11:17:40 A.M. Pacific Standard Time,

gfijig@... writes:

Acta Neurol Belg. 2009 Dec;109(4):294-Ac

Small fiber neuropathy in Charcot-Marie-Small fiber ne

Zambelis T.

EMG Laboratory, Department of Neurology, University of Athens, Aeghinition

Hospital, Athens, Greece.

The aim of this study was to investigate small myelinated (Adelta) and

unmyelinated © fiber function in patients with CMT1A and CMTX

polyneuropathy.

17 CMT1A and 10 Cx32 polyneuropathy patients were investigated with warm

and cold threshold to evaluate small myelinated (Adelta) an unmyelinated ©

somatic fiber function and with sympathetic skin responses (SSR) to

evaluate postganglionic sympathetic fiber function.

Median age and disease duration did not differ between the two groups.

Charcot-Marie-Median age and disease duration did not differ between the two

groups. Charcot-Marie-<WBR>Tooth neuropathy score was higher in CMTX

patients. M

In CMT1A patients warm threshold was abnormal in 72% and cold threshold in

53%. On the contrary, in Cx32 patients group warm and cold threshold was

abnormal in 10 and 20% respectively. SSR was also abnormal in only a small

number of both CMT1A and Cx32 patients (24% and 10% respectively)In

Conclusion: Small fiber function is frequently impaired in CMT1A

polyneuropathy patients.

[Guest guest]

Acta Neurol Belg. 2009 Dec;109(4):294-7.

Small fiber neuropathy in Charcot-Marie-Tooth disease.

Zambelis T.

EMG Laboratory, Department of Neurology, University of Athens, Aeghinition

Hospital, Athens, Greece.

The aim of this study was to investigate small myelinated (Adelta) and

unmyelinated © fiber function in patients with CMT1A and CMTX polyneuropathy.

17 CMT1A and 10 Cx32 polyneuropathy patients were investigated with warm and

cold threshold to evaluate small myelinated (Adelta) an unmyelinated © somatic

fiber function and with sympathetic skin responses (SSR) to evaluate

postganglionic sympathetic fiber function.

Median age and disease duration did not differ between the two groups.

Charcot-Marie-Tooth neuropathy score was higher in CMTX patients. Mean MCV

differed significantly between the two groups in both Median and Ulnar nerve.

In CMT1A patients warm threshold was abnormal in 72% and cold threshold in 53%.

On the contrary, in Cx32 patients group warm and cold threshold was abnormal in

10 and 20% respectively. SSR was also abnormal in only a small number of both

CMT1A and Cx32 patients (24% and 10% respectively).

Conclusion: Small fiber function is frequently impaired in CMT1A polyneuropathy

patients.