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Re: Pleodrugs for CMT

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Hello,

May I ask what are the " human trials will begin before the end of 2010 " ?

Do you mean the treatments or drugs to cure CMT?

Thank you very much.

Caroline

On Thu, Jun 10, 2010 at 8:20 AM, gfijig <gfijig@...> wrote:

>

>

> Pharnext is repositioning drugs already on the market. It mixes drugs in

> new ways, combining them in so-called " pleocompounds " (pleodrugs), and

> administers them in mini-doses to restore normal cell functions while

> reducing side effects. It is an approach known as " network pharmacology " ,

> which a November 8 article in Nature referred to as " the next paradigm in

> drug discovery " .

>

> It's very exciting to me that human trials will begin before the end of

> 2010. I remember back in 1990 or 1991 when the mutation for CMT 1A was

> discovered. Wow, sure have seen alot of progress on CMT in the last 20

> years.

>

> Gretchen

>

>

>

--

May you be well and happy

Caroline

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Caroline,

Yes, I mean for CMT, as the news article stated. I don't know the exact month or

day when human trials will begin. France seems to get things done quickly. As I

stated earlier, Pleodrugs are compounds already on the market that will be

repositioned (mixed) to provide new treatment possibilities. There has been a

vast amount of fundraising for this, and from what I understand there has

already been animal model testing. I do not know what the " compounds " are for,

and no one else knows due to the ethics involved.

Keep following Pharnex for updates. I'll post them here too.

Gretchen

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