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Pleodrugs for CMT

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Pharnext is repositioning drugs already on the market. It mixes drugs in new

ways, combining them in so-called " pleocompounds " (pleodrugs), and administers

them in mini-doses to restore normal cell functions while reducing side effects.

It is an approach known as " network pharmacology " , which a November 8 article in

Nature referred to as " the next paradigm in drug discovery " .

It's very exciting to me that human trials will begin before the end of 2010. I

remember back in 1990 or 1991 when the mutation for CMT 1A was discovered. Wow,

sure have seen alot of progress on CMT in the last 20 years.

Gretchen

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