Re: Some Good CMT Research News

[Guest guest]

Well that is good news. I sure don't mind having CMT for myself but it would be

nice for the CMT kids not to have to learn to live with it.

In a message dated 6/8/2010 10:26:29 A.M. Pacific Daylight Time,

gfijig@... writes:

Update on the Star Initiative from the CMTA.

The NIH completed the high-throughput screening program. Working with

a chemical library of more than 350,000 compounds, the NIH screened

each compound at approximately 7 different dosage levels – resulting

in more than 2 million unique screens.

Out of the 4000 FDA approved drugs, 10 " hits " or candidate medicines

were found. At this point in time, we are not able to divulge the names of

these compounds.

Out of the non-FDA approved drugs, 800 " hits " were discovered.

These 800 hits proved to reduce the amount of PMP 22 in the cells,

without causing any damage to the cells .

A second cell assay, created by Svaren, is being sent to the NIH

this week. The 810 hits discovered from the initial screening will be

tested on Svaren's new assay over the summer and the final results

should be released by the end of August.

At this point, we will know more about when the animal model testing

will occur.

We are extremely hopeful excited about the progress made by the

scientists involved in the STAR program. Never before has such a large

portfolio of over 800 compounds been tested on a cell line in this

fashion.

[Guest guest]

Wow. Since I have HNPP and am totally missing the PMP-22 gene, I hope the

reverse will be true and I could take a supplement that will add the gene,

I'd be OK with injection form too. It sure would be nice to get out of this

wheelchair. :-)

Jeanne

[Guest guest]

My thoughts exactly . Before I leave this

Earth I would like to see a cure or treatment

And then I can go peacefully!

Jackie

Sent from my iPhone

On Jun 9, 2010, at 2:25 AM, MommyToJase@... wrote:

> Well that is good news. I sure don't mind having CMT for myself but

> it would be nice for the CMT kids not to have to learn to live with

> it.

>

>

>

>

>

> In a message dated 6/8/2010 10:26:29 A.M. Pacific Daylight Time,

> gfijig@... writes:

>

> Update on the Star Initiative from the CMTA.

>

> The NIH completed the high-throughput screening program. Working with

> a chemical library of more than 350,000 compounds, the NIH screened

> each compound at approximately 7 different dosage levels – resulting

> in more than 2 million unique screens.

>

> Out of the 4000 FDA approved drugs, 10 " hits " or candidate medicines

> were found. At this point in time, we are not able to divulge the

> names of

> these compounds.

>

> Out of the non-FDA approved drugs, 800 " hits " were discovered.

>

> These 800 hits proved to reduce the amount of PMP 22 in the cells,

> without causing any damage to the cells .

>

> A second cell assay, created by Svaren, is being sent to the NIH

> this week. The 810 hits discovered from the initial screening will be

> tested on Svaren's new assay over the summer and the final results

> should be released by the end of August.

>

> At this point, we will know more about when the animal model testing

> will occur.

>

> We are extremely hopeful excited about the progress made by the

> scientists involved in the STAR program. Never before has such a large

> portfolio of over 800 compounds been tested on a cell line in this

> fashion.

>

>

[Guest guest]

Any drug would not change anything in your genome, but would be able to change

transcription levels of certain genes. A deletion from my understanding would

probably be a little different to treat.

>

> Wow. Since I have HNPP and am totally missing the PMP-22 gene, I hope the

> reverse will be true and I could take a supplement that will add the gene,

> I'd be OK with injection form too. It sure would be nice to get out of this

> wheelchair. :-)

>

>

>

> Jeanne

>

>

>

>

>

>

>

>